国际肿瘤学杂志››2022,Vol. 49››Issue (10): 635-638.doi:10.3760/cma.j.cn371439-20220520-00127
收稿日期:
2022-05-20修回日期:
2022-08-04出版日期:
2022-10-08发布日期:
2022-12-01通讯作者:
赵雪梅 E-mail:zhaoxm@sdfmu.edu.cnReceived:
2022-05-20Revised:
2022-08-04Online:
2022-10-08Published:
2022-12-01Contact:
Zhao Xuemei E-mail:zhaoxm@sdfmu.edu.cn摘要:
DNA损伤修复(DDR)基因在肝癌中存在过表达的现象。研究发现,DDR与肝癌的发生与发展有密切的联系。DDR抑制剂与肝癌化疗、靶向治疗药物间存在协同作用,其可增强放疗的敏感性。部分DDR基因可作为肝癌预后评估的生物标志物。
狄伟华, 赵雪梅. DNA损伤修复在肝癌中的研究进展[J]. 国际肿瘤学杂志, 2022, 49(10): 635-638.
Di Weihua, Zhao Xuemei. Research progress on the relationship between DNA damage repair genes and liver cancer[J]. Journal of International Oncology, 2022, 49(10): 635-638.
[1] | Gillman R, Lopes Floro K, Wankell M, et al. The role of DNA damage and repair in liver cancer[J]. Biochim Biophys Acta Rev Cancer, 2021, 1875(1): 188493. DOI: 10.1016/j.bbcan.2020.188493. doi:10.1016/j.bbcan.2020.188493 |
[2] | Lin J, Shi J, Guo H, et al. Alterations in DNA damage repair genes in primary liver cancer[J]. Clin Cancer Res, 2019, 25(15): 4701-4711. DOI: 10.1158/1078-0432.CCR-19-0127. doi:10.1158/1078-0432.CCR-19-0127pmid:31068370 |
[3] | Xiong Y, Zhang Q, Ye J, et al. Associations between three XRCC1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis of case-control studies[J]. PLoS One, 2018, 13(11): e0206853. DOI: 10.1371/journal.pone.0206853. doi:10.1371/journal.pone.0206853 |
[4] | Kumar N, Raja S, Van Houten B. The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage[J]. Nucleic Acids Res, 2020, 48(20): 11227-11243. DOI: 10.1093/nar/gkaa777. doi:10.1093/nar/gkaa777pmid:33010169 |
[5] | Zhuo Z, Miao L, Hua W, et al. Genetic variations in nucleotide excision repair pathway genes and hepatoblastoma susceptibility[J]. Int J Cancer, 2021, 149(9): 1649-1658. DOI: 10.1002/ijc.33722. doi:10.1002/ijc.33722 |
[6] | Saha J, Bae J, Wang SY, et al. Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma[J]. Nucleic Acids Res, 2021, 49(17): 9836-9850. DOI: 10.1093/nar/gkab743. doi:10.1093/nar/gkab743pmid:34428289 |
[7] | Yue X, Bai C, Xie D, et al. DNA-PKcs: a multi-faceted player in DNA damage response[J]. Front Genet, 2020, 11: 607428. DOI: 10.3389/fgene.2020.607428. doi:10.3389/fgene.2020.607428 |
[8] | Pannunzio NR, Watanabe G, Lieber MR. Nonhomologous DNA end-joining for repair of DNA double-strand breaks[J]. J Biol Chem, 2018, 293(27): 10512-10523. DOI: 10.1074/jbc.TM117.000374. doi:10.1074/jbc.TM117.000374pmid:29247009 |
[9] | Ma M, Rodriguez A, Sugimoto K. Activation of ATR-related protein kinase upon DNA damage recognition[J]. Curr Genet, 2020, 66(2): 327-333. DOI: 10.1007/s00294-019-01039-w. doi:10.1007/s00294-019-01039-wpmid:31624858 |
[10] | Ge C, Vilfranc CL, Che L, et al. The BRUCE-ATR signaling axis is required for accurate DNA replication and suppression of liver cancer development[J]. Hepatology, 2019, 69(6): 2608-2622. DOI: 10.1002/hep.30529. doi:10.1002/hep.30529pmid:30693543 |
[11] | 朱柯亭, 武振汝, 卢徐锋, 等. 肝细胞肝癌中HDAC3的表达及临床意义[J]. 世界华人消化杂志, 2017, 25(10): 922-928. DOI: 10.11569/wcjd.v25.i10.922. doi:10.11569/wcjd.v25.i10.922 |
[12] | Ji H, Zhou Y, Zhuang X, et al. HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition[J]. Cancer Res, 2019, 79(14): 3676-3688. DOI: 10.1158/0008-5472.CAN-18-3767. doi:10.1158/0008-5472.CAN-18-3767pmid:31097476 |
[13] | Boege Y, Malehmir M, Healy ME, et al. A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development[J]. Cancer Cell, 2017, 32(3): 342-359.e10. DOI: 10.1016/j.ccell.2017.08.010. doi:S1535-6108(17)30354-9pmid:28898696 |
[14] | Mo J, Liang H, Su C, et al. DDX3X: structure, physiologic functions and cancer[J]. Mol Cancer, 2021, 20(1): 38. DOI: 10.1186/s12943-021-01325-7. doi:10.1186/s12943-021-01325-7pmid:33627125 |
[15] | Chan CH, Chen CM, Lee YW, et al. DNA damage, liver injury, and tumorigenesis: consequences of DDX3X loss[J]. Mol Cancer Res, 2019, 17(2): 555-566. DOI: 10.1158/1541-7786.MCR-18-0551. doi:10.1158/1541-7786.MCR-18-0551 |
[16] | Shen J, Chen M, Lee D, et al. Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression[J]. Gut, 2020, 69(2): 329-342. DOI: 10.1136/gutjnl-2019-318668. doi:10.1136/gutjnl-2019-318668pmid:31439637 |
[17] | Goldstein M, Kastan MB. The DNA damage response: implications for tumor responses to radiation and chemotherapy[J]. Annu Rev Med, 2015, 66: 129-143. DOI: 10.1146/annurev-med-081313-121208. doi:10.1146/annurev-med-081313-121208pmid:25423595 |
[18] | Chen CC, Chen CY, Cheng SF, et al. Hydroxygenkwanin increases the sensitivity of liver cancer cells to chemotherapy by inhibiting DNA damage response in mouse xenograft models[J]. Int J Mol Sci, 2021, 22(18): 9766. DOI: 10.3390/ijms22189766. doi:10.3390/ijms22189766 |
[19] | Herath NI, Devun F, Herbette A, et al. Potentiation of doxorubicin efficacy in hepatocellular carcinoma by the DNA repair inhibitor DT01 in preclinical models[J]. Eur Radiol, 2017, 27(10): 4435-4444. DOI: 10.1007/s00330-017-4792-1. doi:10.1007/s00330-017-4792-1pmid:28374075 |
[20] | Chen CC, Chen CY, Ueng SH, et al. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair[J]. Cell Death Dis, 2018, 9(5): 543. DOI: 10.1038/s41419-018-0575-0. doi:10.1038/s41419-018-0575-0 |
[21] | Wang C, Tang H, Geng A, et al. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors[J]. Proc Natl Acad Sci U S A, 2020, 117(42): 26356-26365. DOI: 10.1073/pnas.2002917117. doi:10.1073/pnas.2002917117pmid:33020270 |
[22] | Cherng YG, Chu YC, Yadav VK, et al. Induced mitochondrial alteration and DNA damage via IFNGR-JAK2-STAT1-PARP1 pathway facilitates viral hepatitis associated hepatocellular carcinoma aggressiveness and stemness[J]. Cancers (Basel), 2021, 13(11): 2755. DOI: 10.3390/cancers13112755. doi:10.3390/cancers13112755 |
[23] | 周蔚文, 孙晓南. 肝外胆管癌放疗的研究进展[J]. 国际肿瘤学杂志, 2020, 47(7): 431-435. DOI: 10.3760/cma.j.cn371439-20200224-00051. doi:10.3760/cma.j.cn371439-20200224-00051 |
[24] | Sheng H, Huang Y, Xiao Y, et al. ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma[J]. J Immunother Cancer, 2020, 8(1): e000340. DOI: 10.1136/jitc-2019-000340. doi:10.1136/jitc-2019-000340 |
[25] | Xie Y, Liu C, Zhang Y, et al. PKI-587 enhances radiosensitization of hepatocellular carcinoma by inhibiting the PI3K/AKT/mTOR pathways and DNA damage repair[J]. PLoS One, 2021, 16(10): e0258817. DOI: 10.1371/journal.pone.0258817. doi:10.1371/journal.pone.0258817 |
[26] | Gerossier L, Dubois A, Paturel A, et al. PARP inhibitors and radiation potentiate liver cell death in vitro. Do hepatocellular carcinomas have an achilles' heel?[J]. Clin Res Hepatol Gastroenterol, 2021, 45(5): 101553. DOI: 10.1016/j.clinre.2020.09.014. doi:10.1016/j.clinre.2020.09.014 |
[27] | Chen Y, Wang X, Deng X, et al. DNA damage repair status predicts opposite clinical prognosis immunotherapy and non-immunotherapy in hepatocellular carcinoma[J]. Front Immunol, 2021, 12: 676922. DOI: 10.3389/fimmu.2021.676922. doi:10.3389/fimmu.2021.676922 |
[28] | 李华兰. XPC、ERCC1及XPF表达与肝细胞癌临床病理特征及预后的相关性研究[D]. 南宁: 广西医科大学, 2019. DOI: 10.27038/d.cnki.ggxyu.2019.000139. doi:10.27038/d.cnki.ggxyu.2019.000139 |
[29] | Liao X, Li Y, Li H, et al. Expression and clinical significance of ERCC1 and XPF in human hepatocellular carcinoma[J]. Onco Targets Ther, 2020, 13: 1059-1072. DOI: 10.2147/OTT.S237916. doi:10.2147/OTT.S237916 |
[30] | Chen X, Legrand AJ, Cunniffe S, et al. Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients[J]. Cell Oncol (Dordr), 2018, 41(5): 527-539. DOI: 10.1007/s13402-018-0390-8. doi:10.1007/s13402-018-0390-8 |
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