国际肿瘤学杂志››2024,Vol. 51››Issue (10): 650-654.doi:10.3760/cma.j.cn371439-20240429-00109

• 综述 •上一篇下一篇

肿瘤细胞源性外泌体在结直肠癌转移前微环境形成中的作用

陈洁, 徐红(), 陈雨甜

  1. 苏州大学附属第一医院肿瘤科,苏州 215000
  • 收稿日期:2024-04-29修回日期:2024-05-16出版日期:2024-10-08发布日期:2024-12-04
  • 通讯作者:徐红 E-mail:13301549066@163.com

Role of tumor cell-derived exosomes in the pre-metastatic niche formation in colorectal cancer

Chen Jie, Xu Hong(), Chen Yutian

  1. Department of Oncology, First Affiliated Hospital of Soochow University, Suzhou 215000, China
  • Received:2024-04-29Revised:2024-05-16Online:2024-10-08Published:2024-12-04
  • Contact:Xu Hong E-mail:13301549066@163.com

摘要:

远处转移是导致晚期结直肠癌患者死亡的主要原因,肿瘤细胞源性外泌体作为信息传递的介质,广泛参与结直肠癌转移前微环境形成的各个环节。深入研究外泌体在转移前微环境形成中的机制,可为结直肠癌的靶向治疗和预测肿瘤进展提供新的思路。

关键词:外泌体,肿瘤微环境,结直肠肿瘤,肿瘤转移,转移前微环境

Abstract:

Distant metastasis is the main cause of death in patients with advanced colorectal cancer, and tumor cell-derived exosomes, as mediators of information transfer, are widely involved in all aspects of pre-metastatic niche formation in colorectal cancer. In-depth study of the mechanism of exosomes in the formation of pre-metastatic niche can provide new ideas for targeted therapy and prediction of tumor progression in colorectal cancer.

Key words:Exosomes,Tumor microenvironment,Colorectal neoplasms,Neoplasm metastasis,Pre-metastatic niche