国际肿瘤学杂志››2014,Vol. 41››Issue (3): 203-205.doi:10.3760/cma.j.issn.1673-422X.2014.03.013

• 综述 •上一篇下一篇

组织学分子标志物对ⅢA(N2)期非小细胞肺癌预后意义的研究进展

唐仕敏, 李文辉, 常莉

  1. 650118 昆明医科大学第三附属医院放疗科
  • 出版日期:2014-03-08发布日期:2014-03-17
  • 通讯作者:李文辉,E-mail: wenhuili64@aliyun.com E-mail:wenhuili64@aliyun.com
  • 基金资助:
    国家自然科学基金(81101693)

Significance of histologic molecular markers for prognosis of the ⅢA (N2) phase non-small cell lung cancer

TANG Shi-Min, LI Wen-Hui, CHANG Li

  1. Department of Radiation Oncology, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
  • Online:2014-03-08Published:2014-03-17
  • Contact:Li Wenhui, E-mail: wenhuili64@aliyun.com E-mail:wenhuili64@aliyun.com

摘要:ⅢA(N2)期非小细胞肺癌预后因素繁多,与其预后相关的组织学分子标志物主要有多药耐药基因、生长因子类、黏蛋白4、胰岛素样生长因子2、增殖细胞核抗原以及磷酸酶张力蛋白酶等。这些基因的不同表达或许可以把N2期非小细胞肺癌分成不同的分子亚型,从而更有效地指导临床。

关键词:组织学,生物学标记,肿瘤分期,癌,非小细胞肺,预后

Abstract:Prognosis factors of ⅢA (N2) phase nonsmall cell lung cancer are various. The histological molecular markers are mainly about multiresistant gene, growth factors, mucin 4, insulinlike growth factor-2, Ki-67, PTEN and so on. Different expressions of these genes may divide the N2 non-small-cell lung cancer into different molecular subtypes, which is more effective to guide clinical therapy.

Key words:Histology,Biological markers,Neoplasm staging,Carcinoma, nonsmall cell lung,Prognosis