国际肿瘤学杂志››2015,Vol. 42››Issue (1): 74-76.doi:10.3760/cma.j.issn.1673-422X.2015.01.020
张宁, 尤建宇, 国维纳, 赵宝林
收稿日期:
2014-06-18修回日期:
2014-08-05出版日期:
2015-01-08发布日期:
2015-01-07通讯作者:
赵宝林 E-mail:zhaobl@163.comZhang Ning, You Jianyu, Guo Weina, Zhao Baolin
Received:
2014-06-18Revised:
2014-08-05Online:
2015-01-08Published:
2015-01-07Contact:
Zhao Baolin E-mail:zhaobl@163.com摘要:目前,医学界普遍承认治疗骨肉瘤的最佳方法是基因治疗,常用的有抑癌基因治疗、反义基因治疗、自杀基因治疗、免疫基因治疗、联合基因治疗等。但是无论哪种基因治疗方法,都必须具备安全的基因载体。骨肉瘤的基因治疗方法近几年有所突破,在广泛应用的基础上,还应进一步强调基因载体的重要性。
张宁, 尤建宇, 国维纳, 赵宝林. 骨肉瘤基因治疗的现状分析[J]. 国际肿瘤学杂志, 2015, 42(1): 74-76.
Zhang Ning, You Jianyu, Guo Weina, Zhao Baolin. Status analysis of gene therapy in osteosarcoma[J]. Journal of International Oncology, 2015, 42(1): 74-76.
[1] Rainusso N, Brawley VS, Ghazi A, et al. Immunotherapy targeting HER2 with genetically modified T cells eliminates tumorinitiating cells in osteosarcoma[J]. Cancer Gene Ther, 2012, 19(3): 212-217. [2] Daft PG, Yuan K, Warram JM, et al. AlphaCaMKII plays a critical role in determining the aggressive behavior of human osteosarcoma[J]. Mol Cancer Res, 2013, 11(4): 349-359. [3] Baamonde A, CurtoReyes V, Juárez L, et al. Antihyperalgesic effects induced by the IL1 receptor antagonist anakinra and increased IL1 beta levels in inflamed and osteosarcomabearing mice[J]. Life Sci, 2011, 81(8): 673-682. [4] Liebau C, Roesel C, Schmidt S, et al. Immunotherapy by gene transfer with plasmids encoding IL12/IL18 is superior to IL23/IL18 gene transfer in a rat osteosarcoma model[J]. Anticancer Res, 2004, 24(5A): 2861-2867. [5] Strander H. Interferons and osteosarcoma[J]. Cytokine Growth Factor Rev, 2007, 18(56): 373380. [6] Fulda S, Debatin KM. 5Aza2′deoxycytidine and IFNgamma cooperate to sensitize for TRAILinduced apoptosis by upregulating caspase8[J]. Oncogene, 2006, 25(37): 5125-5133. [7] Gauthaman K, Fong CY, Arularasu S, et al. Human Wharton′s jelly stem cell conditioned medium and cellfree lysate inhibit human osteosarcoma and mammary carcinoma cell growth in vitro and in xenograft mice[J]. J Cell Biochem, 2013, 114(2): 366-377. [8] Wang YC, Zheng LH, Ma BA, et al. Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma[J]. Acta Histochem, 2011, 113(4): 402-408. [9] Tsang WP, Chau SP, Fung KP, et al. Modulation of multidrug resistanceassociated protein 1 (MRP1) by p53 mutant in Saos2 cells[J]. Cancer Chemother Pharmacol, 2003, 51(2): 161-166. [10] Xie XK, Yang DS, Ye ZM, et al. Construction of antisense cmyc recombinant adenovirus and its antitumor effects on osteosarcoma cell lines MG63 and U2OS[J]. Ai Zheng, 2005, 24(3): 292-297. [11] Martelli L, Di Mario F, Botti P, et al. Accumulation, platinumDNA adduct formation and cytotoxicity of cisplatin, oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines, characterized by p53 wildtype status[J]. Biochem Pharmacol, 2007, 74(1): 20-27. [12] Ketola A, Mtt AM, Pasanen T, et al. Osteosarcoma and chondrosarcoma as targets for virus vectors and herpes simplex virus thymidine kinase/ganciclovir gene therapy[J]. Int J Mol Med, 2004, 13(5): 705-710. [13] Seto M, Yamazaki T, Sonoda J, et al. Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy[J]. Oncol Rep, 2002, 9(2): 337-340. [14] Oosterhoff D, Witlox MA, van Beusechem VW, et al. Genedirected enzyme prodrug therapy for osteosarcoma: sensitization to CPT11 in vitro and in vivo by adenoviral delivery of a gene encoding secreted carboxylesterase2[J]. Mol Cancer Ther, 2003, 2(8): 765-771. [15] Lafleur EA, Jia SF, Worth LL, et al. Interleukin (IL)12 and IL12 gene transfer upregulate Fas expression in human osteosareoma and breast cancer cells[J]. Cancer Res, 2001, 61(10): 4066-4071. [16] Osaki M, Takeshita F, Sugimoto Y, et al. MicroRNA143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease13 expression[J]. Mol Ther, 2011, 19(6):1123-1130. [17] Nagamori M, Kawaguchi S, Murakami M, et al. In vivo immunogenicity of osteosarcoma cells that express B71a, an alternatively spliced form of B71[J]. Anticancer Res, 2009, 22(4): 2009-2013. [18] Posthumadeboer J, van Egmond PW, Helder MN, et al. Targeting JNKinteractingprotein1 (JIP1) sensitises osteosarcoma to doxorubicin[J]. Oncotarget, 2012, 3(10): 1169-1181. [19] Zhang ZY, Wang LQ, Fu CF, et al. Combination of targeting geneviro therapy with recombinant Fowlpox viruses with HN and VP3 genes on mouse osteosarcoma[J]. Eur Rev Med Pharmacol Sci, 2013, 17(6): 767-776. [20] Okumura K, Nakase M, Nakamura S, et al. Bax gene therapy for human osteosarcoma using cationic liposomes in vivo[J]. Once Rep, 2012, 17(4): 769-773. |
[1] | 王培鑫, 赵军, 徐世红, 姜朝阳, 王小强, 杨红娟.铁死亡相关机制在骨肉瘤中的应用进展[J]. 国际肿瘤学杂志, 2024, 51(5): 308-311. |
[2] | 王子豪, 王宇, 杨鑫, 何艺, 莫兴奎, 袁涛.铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 239-244. |
[3] | 马小平, 常君丽, 孙星媛, 杨燕萍.长非编码RNA调控骨肉瘤耐药机制的研究进展[J]. 国际肿瘤学杂志, 2023, 50(1): 51-54. |
[4] | 周仁邦, 张仲传, 许志远, 朱勋兵.miR-219a-5p通过负调控HMGA2抑制骨肉瘤U2OS细胞增殖、侵袭和迁移[J]. 国际肿瘤学杂志, 2022, 49(4): 193-198. |
[5] | 李炳亮, 杨娅, 黄英丽, 司文, 李兴伟, 张元民, 卞继超, 陈语.miR-20a-5p靶向KDM6B对骨肉瘤细胞增殖、迁移和侵袭能力的影响[J]. 国际肿瘤学杂志, 2021, 48(2): 65-73. |
[6] | 杨晓1,李思2,彭锦3,王琳4,吴衣论4,冯颖2.质膜型唾液酸酶NEU3活性对骨肉瘤MG-63细胞增殖与凋亡的影响[J]. 国际肿瘤学杂志, 2019, 46(4): 193-198. |
[7] | 贺启华.微小RNA-24对骨肉瘤细胞U2OS体外增殖与迁移能力的影响及作用机制[J]. 国际肿瘤学杂志, 2017, 44(7): 490-495. |
[8] | 袁源, 李松霖, 王忠华, 沈会华, 李悟, 王卫东.吴茱萸碱抑制Wnt/β-catenin信号通路诱导骨肉瘤MG-63细胞凋亡[J]. 国际肿瘤学杂志, 2017, 44(2): 86-90. |
[9] | 王伟,李召辉,郑晓霞,崔玉英.ErbB3在骨肉瘤细胞株Saos-2中的表达及其意义[J]. 国际肿瘤学杂志, 2016, 43(8): 593-596. |
[10] | 吴进, 陈志达, 曾文容, 林斌, 吴欣宇, 刘庆军.HERG基因调控NF-κB通道抑制骨肉瘤恶性表型的研究[J]. 国际肿瘤学杂志, 2016, 43(7): 508-514. |
[11] | 沈国琪,张春林.受体酪氨酸激酶在骨肉瘤和尤文肉瘤中的作用[J]. 国际肿瘤学杂志, 2015, 42(7): 551-553. |
[12] | 任慧文,杨澄,苏宏伟,李宏伟.微小RNA表达比在骨肉瘤中的预测作用[J]. 国际肿瘤学杂志, 2014, 41(8): 708-711. |
[13] | 杨澄, 苏宏伟, 任慧文, 李宏伟.骨肿瘤的发生发展及转移[J]. 国际肿瘤学杂志, 2014, 41(7): 533-536. |
[14] | 牛鑫, 邓志华.慢病毒载体及其在肿瘤基因治疗中的研究应用[J]. 国际肿瘤学杂志, 2014, 41(6): 422-424. |
[15] | 郭雨平, 汪得喜.肺癌靶向基因的研究及价值[J]. 国际肿瘤学杂志, 2013, 40(7): 512-515. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||