吉西他滨联合化疗治疗复发或转移性乳腺癌

摘要/Abstract

摘要：吉西他滨联合化疗是治疗复发或转移性乳腺癌的有效方案。除了标准的联合紫杉醇3周方案之外，根据个体化治疗原则，也可选择不同的联合药物如多西他赛或铂类，或是采取不同的给药频率和剂量以及延长给药周期进行维持。吉西他滨联合紫杉类药物对于有内脏转移、激素受体阴性的患者临床获益更加明显，初步循证结果证明了后续进行同方案维持治疗的可行性。另外，吉西他滨联合顺铂方案是治疗转移性三阴乳腺癌更优的选择。

关键词:乳腺肿瘤,药物疗法,吉西他滨

Abstract:Gemcitabine based chemotherapy is effective in recurrent or metastatic breast cancer. Besides the 3 week regimen in combination with paclitaxel, individualized treatments are also applied to combine gemcitabine with other agents such as docetaxel or platinum, or to administer by different frequency or dose, or to continuously maintain on the treatment as an extension to front line. It is demonstrated that gemcitabine in combination with taxanes can obtain survival benefit, largely in patients with visceral metastasis or hormone receptor negative. Initial evidence has also supported the feasibility of continuous maintenance. Finally, gemcitabine in combination with cisplatin is a better option for the metastatic triple negative breast cancer.

Key words:Breast neoplasms,Drug therapy,Gemcitabine

佟仲生,徐聪,王晋. 吉西他滨联合化疗治疗复发或转移性乳腺癌[J]. 国际肿瘤学杂志, 2015, 42(10): 769-772.

Tong Zhongsheng, Xu Cong, Wang Jin. Gemcitabine in combination with chemotherapy in the treatment of recurrent or metastatic breast cancer[J]. Journal of International Oncology, 2015, 42(10): 769-772.

参考文献

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