循环肿瘤DNA在乳腺癌内分泌治疗耐药中的应用

摘要/Abstract

摘要：内分泌治疗可以让绝大多数雌激素受体阳性乳腺癌患者受益，但随着内分泌治疗的进行，很多患者不可避免地出现内分泌耐药。在治疗过程中，持续监测耐药突变情况将为临床治疗提供巨大的帮助。循环肿瘤DNA（ctDNA）以其无创、方便、快速及反映肿瘤整体情况等优势引起了人们的注意。新一代测序和微滴数字PCR技术相继成熟，使耐药突变监测系统的建立成为了可能。

关键词:乳腺肿瘤,内分泌治疗,循环肿瘤DNA

Abstract:Although most hormonereceptor positive breast cancer patients initially respond to endocrine treatment, they will eventually acquire resistance to endocrine therapy. Therefore, during clinical treatment, it is of great importance to continuously monitor for resistant mutations. Circulating tumor DNA (ctDNA) has become more prevalent because it is noninvasive, convenient, rapid, and can quickly assess the overall situation of the tumor. With the maturity of nextgeneration sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR), the establishment of endocrine treatment resistance mutation monitoring system has become possible.

Key words:Breast neoplasms,Endocrine therapy,Circulating tumor DNA

刘斌亮,马飞,曾益新. 循环肿瘤DNA在乳腺癌内分泌治疗耐药中的应用[J]. 国际肿瘤学杂志, 2017, 44(10): 779-782.

Liu Binliang, Ma Fei, Zeng Yixin. Application of circulating tumor DNA in endocrine therapy resistance of breast cancer[J]. Journal of International Oncology, 2017, 44(10): 779-782.

参考文献

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