国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (4): 295-298.

• 综述 •上一篇下一篇

胃肠间质瘤生物标志物改变与患者预后及靶向药物疗效的关系

孙闻, 陈锦飞

  1. 210006，南京，南京医科大学附属南京市第一医院肿瘤内科
  • 出版日期:2012-04-08发布日期:2012-03-28
  • 通讯作者:陈锦飞，E-mail：jinfeichen@sohu.com E-mail:jinfeichen@sohu.com

Variations of biomarkers in gastrointestinal stromal tumor and prognoses of the patients and targeted drug sensitivity

SUN Wen, CHEN Jin-Fei

  1. Department of Oncology,the First Hospital of Nanjing ,Affiliated Hospital of Nanjing Medical University, Nanjing 210006, China

  • Online:2012-04-08Published:2012-03-28
  • Contact:Corresponding author: CHEN Jin-fei, E-mail: jinfeichen@sohu.com E-mail:jinfeichen@sohu.com

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摘要：多项研究发现胃肠间质瘤生物标志物改变影响患者的预后，包括1p、13q、14q、15q或22q等数个染色体失调及细胞核或线粒体的微卫星不稳定现象，此外还有多种癌基因及抑癌基因的改变。kit及血小板衍生生长因子受体a基因突变不仅影响着胃肠间质瘤的进展及转移，还与胃肠间质瘤对靶向药物的敏感性有关，进而影响患者预后。

关键词:胃肠道间质肿瘤,生物学标记,预后,分子靶向治疗

Abstract:Many researches show that the prognosis of gastrointestinal stromal tumor (GIST) are related to numerous variations of biomarkers such as numeric chromosomal aberrations or nuclear/mitochondrial microsatellite instability. In addition, the changes of proto-oncogene and tumor-suppressor gene are found to influence the prognosis of GIST. The kit and platelet-derived growth factor receptor a mutation are correlated with GIST progression, metastasis and targeted drug sensitivity, and then influence the prognosis of GIST.

Key words:Gastrointestinal stromal tumors,Biological markers,Prognosis,Molecular targeted therapy