国际肿瘤学杂志››2012,Vol. 39››Issue (6): 439-442.

• 综述 •上一篇下一篇

DNA甲基化在Barrett食管和食管腺癌的研究

李波,凌志强,毛伟敏

  1. 杭州,浙江省肿瘤医院 浙江省肿瘤研究所
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:毛伟敏,E-mail: maowm1218@163.com E-mail:maowm1218@163.com

DNA methylation in Barrett esophagus and esophageal adenocarcinoma

LI Bo, LING Zhi-qiang, MAO Wei-min

  1. Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:MAO Wei-min, E-mail: maowm1218@163.com E-mail:maowm1218@163.com

摘要:近年来大量研究表明,肿瘤相关基因启动子区的高甲基化是引发食管腺癌的重要原因之一,并与肿瘤的分化、侵袭、转移、分期和预后等密切相关,可作为食管腺癌临床检测和治疗的新靶点。

关键词:DNA甲基化,Barrett食管,食管肿瘤,腺癌

Abstract:In recent years, a large number of researches show that the tumor related gene promoter hypermethylation is an important reason of esophageal adenocarcinoma and closely associated with the differentiation, invasion, metastasis, staging and prognosis of tumors. It might be used as a new target for the clinical detection and therapy of esophageal adenocarcinoma.

Key words:DNA methylation,Barrett′s esophagus,Esophageal neoplasms,Adenocarcinoma