国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (8): 591-593.

• 综述 •上一篇下一篇

P2X7受体与乳腺癌的发生和发展

谭超,韩莉

  1. 443002 宜昌，三峡大学第一临床医学院&宜昌市中心人民医院检验科 三峡大学医学院
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:韩莉，E-mail: hlyyh@ctgu.edu.cn E-mail:hlyyh@ctgu.edu.cn

P2X7 receptors in the genesis and development of breast cancer

TAN Chao, HAN Li

  1. First Clinical Medical School of Three Gorges University & Clinical Laboratory of Yichang Central People′s Hospital； Medical Science College of Three Gorges University, Yichang 443002, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:HAN Li， Email: hlyyh@ctgu.edu.cn E-mail:hlyyh@ctgu.edu.cn

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被引次数

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摘要：P2X7受体是腺甘三磷酸（ATP）门控的离子通道，对二价阳离子有较强的选择性，属于嘌呤能P2受体家族。P2X7受体参与细胞信号传导、细胞因子的分泌等多种生理功能。近几年研究发现P2X7受体通过增加氧化、磷酸化及细胞内ATP的储备，介导细胞的存活与生长。在乳腺癌中P2X7受体表达异常，活化的P2X7受体激活位于细胞质内的丝裂原活化蛋白激酶（MAPK），后者受到刺激后磷酸化进入核内，引起细胞内一系列蛋白激酶的活化，进而影响乳腺癌的发生发展。

关键词:受体,嘌呤能P2,乳腺肿瘤,腺苷三磷酸

Abstract:P2X7 receptors, belonging to purinergic P2 receptor family, are ATPgated cation channels, which can choose the bivalent cations freely. P2X7 receptors join in cell signal conduction and the excretion of the cytokines and other physical functions. In recent years, researchers have discovered P2X7 receptors mediate the cells to live and grow by increasing oxidation and phosphorylation and intracellular ATP reserve. In breast cancer, the P2X7 receptors express abnormally, and can activate the MAPK lied in cytoplasm. The phosphorylated MAPK enter the nucleus and activates a series of protein kinases, and then affects the genesis and development of breast cancer.

Key words:Receptors, purinergic P2,Breast neoplasms,Adenosine triphosphate