国际肿瘤学杂志››2013,Vol. 40››Issue (2): 120-122.

• 综述 •上一篇下一篇

肺腺癌发展模式

杨振宇, 樊志文, 张雷

  1. 410013长沙,中南大学湘雅医学院临床医学专业
  • 出版日期:2013-02-08发布日期:2013-01-25
  • 通讯作者:张雷,E-mail:chinaray728@gmail.com E-mail:chinaray728@gmail.com

Lung adenocarcinoma progression schema

YANG Zhen-Yu, FAN Zhi-Wen, ZHANG Lei

  1. Clinical Medical Specialty,Xiangya School of Medicine, Central South University , Changsha 410013, China
  • Online:2013-02-08Published:2013-01-25
  • Contact:Corresponding author: ZHANG Lei, E-mail: chinaray728@gmail.com E-mail:chinaray728@gmail.com

摘要:目前普遍认为肺腺癌遵循直线式多阶段的发展模式,即癌前病变发展为原位腺癌,再进展为微浸润性腺癌,最后有些肺腺癌发生扩散。然而近期研究揭示,并非所有的肺腺癌亚型都遵循直线式的发展模式,某些亚型符合一种非直线式的发展模式。对这两种发展模式进行探讨有助于肺腺癌的早期诊断。

关键词:肺肿瘤,DNA甲基化,病因学

Abstract:Lung adenocarcinoma is usually thought to follow a linear multistep progression schema, that isprecancerouslesions progress to adenocarcinoma in situ, and progress to micro-invasive adenocarcinoma, eventually some lung adenocarcinoma happen diffusion. However, recent ?ndings reveal that this linear progression schema might not occur in all lung adenocarcinoma subtypes, and some subtypes show a kind ofnon-linearprogressionschema. The study of these two kinds of schemas can help for early detection of lung adenocarcinoma.

Key words:Lung neoplasms,DNA methylation,Etiology