国际肿瘤学杂志››2016,Vol. 43››Issue (6): 462-464.doi:10.3760/cma.j.issn.1673-422X.2016.06.017
晏芾,于韶荣,曹海霞,冯继锋
收稿日期:
2015-10-17出版日期:
2016-06-08发布日期:
2016-04-27通讯作者:
冯继锋 E-mail:fjif@vip.sina.com基金资助:
江苏省自然科学基金(BK20141016、BK20141017)
Yan Fei, Yu Shaorong, Cao Haixia, Feng Jifeng
Received:
2015-10-17Online:
2016-06-08Published:
2016-04-27Contact:
Feng Jifeng E-mail:fjif@vip.sina.comSupported by:
Natural Science Foundation of Jiangsu Province of China (BK20141016, BK20141017)
摘要:研究表明外泌体可通过介导细胞间通讯参与乳腺癌的发生发展过程,促进肿瘤转移和耐药,影响肿瘤患者的治疗效果。外泌体与乳腺癌临床分期及预后的关系密切,在乳腺癌早期诊断和生物治疗中具有潜在的临床应用价值,可为乳腺癌的治疗提供新的希望。
晏芾,于韶荣,曹海霞,冯继锋. 外泌体在乳腺癌发病中的作用机制[J]. 国际肿瘤学杂志, 2016, 43(6): 462-464.
Yan Fei, Yu Shaorong, Cao Haixia, Feng Jifeng. Mechanism of exosome in the pathogenesis of breast cancer[J]. Journal of International Oncology, 2016, 43(6): 462-464.
[1] Lowry MC, Gallagher WM, O′Driscoll L. The role of exosomes in breast cancer[J]. Clin Chem, 2015, 61(12): 1457-1465. DOI: 10.1373/clinchem.2015.240028. [2] Villagrasa A, lvarez PJ, Osuna A, et al. Exosomes derived from breast cancer cells, small trojan horses?[J]. J Mammary Gland Biol Neoplasia, 2014, 19(34): 303-313. DOI: 10.1007/s10911-015-9332-5. [3] Xu R, Greening DW, Rai A, et al. Highlypurified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct[J]. Methods, 2015, 87: 11-25. DOI: 10.1016/j.ymeth.2015.04.008. [4] Sun Y, Liu J. Potential of cancer cellderived exosomes in clinical application: a review of recent research advances[J]. Clin Ther, 2014, 36(6): 863-872. DOI: 10.1016/j.clinthera.2014.04.018. [5] Hsu C, Morohashi Y, Yoshimura S, et al. Regulation of exosome secretion by Rab35 and its GTPaseactivating proteins TBC1D10AC[J]. J Cell Biol, 2010, 189(2): 223-232. DOI: 10.1083/jcb.200911018. [6] Cai Z, Yang F, Yu L, et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway[J]. J Immunol, 2012, 188(12): 59545961. DOI: 10.4049/jimmunol.1103466. [7] Yuyama K, Sun H, Mitsutake S, et al. Sphingolipidmodulated exosome secretion promotes clearance of amyloidbeta by microglia[J]. J Biol Chem, 2012, 287(14): 10977-10989. DOI: 10.1074/jbc.M111.324616. [8] Ge Q, Zhou Y, Lu J, et al. miRNA in plasma exosome is stable under different storage conditions[J]. Molecules, 2014, 19(2): 1568-1575. DOI: 10.3390/molecules19021568. [9] O′Brien K, Rani S, Corcoran C, et al. Exosomes from triplenegative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells[J]. Eur J Cancer, 2013, 49(8): 1845-1859. DOI: 10.1016/j.ejca.2013.01.017. [10] Tang XJ, Sun XY, Huang KM, et al. Therapeutic potential of CART cellderived exosomes: a cellfree modality for targeted cancer therapy [J]. Oncotarget, 2015, 6(42): 44179-44190. DOI: 10.18632/oncotarget.6175. [11] Ostenfeld MS, Jeppesen DK, Laurberg JR, et al. Cellular disposal of miR23b by RAB27dependent exosome release is linked to acquisition of metastatic properties[J]. Cancer Res, 2014, 74(20): 5758-5771. DOI: 10.1158/00085472.CAN-13-3512. [12] Thompson CA, Purushothaman A, Ramani VC, et al. Heparanase regulates secretion, composition, and function of tumor cellderived exosomes[J]. J Biol Chem, 2013, 288(14): 10093-10099. DOI: 10.1074/jbc.C112.444562. [13] Wang L, Xie Y, Ahmed KA, et al. Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice[J]. Breast Cancer Res Treat, 2013, 140(2): 273-284. DOI: 10.1007/s10549-013-2626-7. [14] Higginbotham JN, Demory Beckler M, Gephart JD, et al. Amphiregulin exosomes increase cancer cell invasion[J]. Curr Biol, 2011, 21(9): 779-786. DOI: 10.1016/j.cub.2011.03.043. [15] Singh R, Pochampally R, Watabe K, et al. Exosomemediated transfer of miR10b promotes cell invasion in breast cancer[J]. Mol Cancer, 2014, 13:256. DOI: 10.1186/1476-4598-13-256. [16] Luga V, Zhang L, ViloriaPetit AM, et al. Exosomes mediate stromal mobilization of autocrine WntPCP signaling in breast cancer cell migration[J]. Cell, 2012, 151(7): 1542-1556. DOI: 10.1016/j.cell.2012.11.024. [17] Zhou W, Fong MY, Min Y, et al. Cancersecreted miR105 destroys vascular endothelial barriers to promote metastasis[J]. Cancer Cell, 2014, 25(4): 501-515. DOI: 10.1016/j.ccr.2014.03.007. [18] Ciravolo V, Huber V, Ghedini GC, et al. Potential role of HER2overexpressing exosomes in countering trastuzumabbased therapy[J]. J Cell Physiol, 2012, 227(2): 658-667. DOI: 10.1002/jcp.22773. [19] Wei Y, Lai X, Yu S, et al. Exosomal miR221/222 enhances tamoxifen resistance in recipient ERpositive breast cancer cells[J]. Breast Cancer Res Treat, 2014, 147(2): 423-431. DOI: 10.1007/s10549-014-3037-0. [20] Zeitzer JM, Nouriani B, Neri E, et al. Correspondence of plasma and salivary cortisol patterns in women with breast cancer[J]. Neuroendocrinology, 2014, 100(23): 153-161. DOI: 10.1159/000367925. [21] Lau CS, Wong DT. Breast cancer exosomelike microvesicles and salivary gland cells interplay alters salivary gland cellderived exosomelike microvesicles in vitro[J]. PLoS One, 2012, 7(3): e33037. DOI: 10.1371/journal.pone.0033037. [22] Khan S, Bennit HF, Turay D, et al. Early diagnostic value of survivin and its alternative splice variants in breast cancer[J]. BMC Cancer, 2014, 14:176. DOI: 10.1186/1471-2407-14-176. |
[1] | 王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369. |
[2] | 萨蔷, 徐航程, 王佳玉.乳腺癌免疫治疗研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 227-234. |
[3] | 杨智, 陆以乔, 顾花艳, 丁佳玲, 郭贵龙.肿瘤微环境介导乳腺癌靶向治疗耐药的研究进展[J]. 国际肿瘤学杂志, 2024, 51(4): 235-238. |
[4] | 李书月, 马辰莺, 周菊英, 徐晓婷, 秦颂兵.寡转移非小细胞肺癌的放疗进展[J]. 国际肿瘤学杂志, 2024, 51(3): 170-174. |
[5] | 刘博翰, 黄俊星.液体活检技术在食管鳞状细胞癌中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(2): 105-108. |
[6] | 孙国宝, 杨倩, 庄庆春, 高斌斌, 孙晓刚, 宋伟, 沙丹.结直肠癌肝转移组织病理学生长方式研究进展[J]. 国际肿瘤学杂志, 2024, 51(2): 114-118. |
[7] | 陈波光, 王苏贵, 张永杰.血清胆碱酯酶与炎症标志物在ⅠA~ⅢA期乳腺癌预后中的作用[J]. 国际肿瘤学杂志, 2024, 51(2): 73-82. |
[8] | 顾花艳, 朱腾, 郭贵龙.乳房微生物群与乳腺癌:现状与未来[J]. 国际肿瘤学杂志, 2024, 51(1): 55-58. |
[9] | 王景, 许文婷.中性粒细胞与淋巴细胞比值、癌胚抗原联合凝血指标对直径≤1.0 cm的良恶性乳腺结节鉴别诊断价值研究[J]. 国际肿瘤学杂志, 2023, 50(9): 520-526. |
[10] | 冯诚天, 黄芙蓉, 曹世玉, 王健宇, 南丁阿比雅思, 姜永冬, 朱娟英.HER2阳性乳腺癌患者HER2表达水平与影像学特征的关系[J]. 国际肿瘤学杂志, 2023, 50(9): 527-531. |
[11] | 冯东旭, 吴炜, 高平发, 王军, 施丽娟, 陈大伟, 李文兵, 张美峰.miR-451通过调控Rho/ROCK1信号通路对乳腺癌细胞糖酵解及凋亡的影响[J]. 国际肿瘤学杂志, 2023, 50(8): 449-456. |
[12] | 张露, 蒋华, 林州, 马辰莺, 徐晓婷, 王利利, 周菊英.免疫检查点抑制剂治疗复发转移性宫颈癌的疗效及预后分析[J]. 国际肿瘤学杂志, 2023, 50(8): 475-483. |
[13] | 张渊, 白芷玉, 李琪, 冯勤梅.外泌体在恶性肿瘤中的研究现状[J]. 国际肿瘤学杂志, 2023, 50(8): 484-488. |
[14] | 王文德, 曾德.乳腺癌内分泌治疗耐药的机制研究进展[J]. 国际肿瘤学杂志, 2023, 50(6): 352-356. |
[15] | 李青珊, 谢鑫, 张楠, 刘帅.放疗联合系统治疗在乳腺癌中的应用进展[J]. 国际肿瘤学杂志, 2023, 50(6): 362-367. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||