钠氢交换体1在肿瘤微环境中的作用

摘要/Abstract

摘要：由于细胞外酸化和细胞内碱化造成的细胞内外pH值梯度的反转是肿瘤代谢微环境的一个重要特征。钠氢交换体1（NHE1）广泛存在于各种细胞的细胞膜上，并在调节细胞内外酸碱平衡及细胞体积中起重要作用。NHE1对肿瘤微环境具有调控作用，并参与恶性肿瘤的侵袭和迁移，可能成为抗肿瘤治疗潜在的新靶点。

关键词:酸碱平衡,肿瘤浸润,细胞运动,肿瘤微环境,钠氢交换体1

Abstract:The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment. Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells, which plays a critical role in intracellular pH and cell volume homeostasis. NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion, which may be a potential new target in anticancer therapy.

Key words:Acidbase equilibrium,Neoplasm invasiveness,Cell movement,Tumor microenvironment,Sodium hydrogen exchanger isoform 1

王伟,杨学军. 钠氢交换体1在肿瘤微环境中的作用[J]. 国际肿瘤学杂志, 2017, 44(3): 205-208.

Wang Wei, Yang Xuejun. Role of sodium hydrogen exchanger isoform 1 in tumor microenvironment[J]. Journal of International Oncology, 2017, 44(3): 205-208.

参考文献

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