关键词:肿瘤转移,新生血管化,病理性,肿瘤细胞来源的外泌体,上皮间质转化

Abstract:Exosomes are microvesicles ranging from approximately 40-150 nm in size, which mediate the exchange of information between cells by releasing proteins, nucleic acids, etc. Tumor-derived exosomes (TEXs) may facilitate tumor metastasis through various mechanisms such as forming the premetastatic niche in the terminal organs, they can regulate immune cells and immune-related molecules in the tumor microenvironment to promote tumor immune escape, they can also induce tumor angiogenesis and increase vascular permeability, promoting the epithelial-mesenchymal transformation of tumor cells, etc. Understanding the mechanism of TEXs in tumor metastasis can provide new ideas for effective prevention and treatment of tumor metastasis.

Key words:Neoplasm metastasis,Neovascularization, pathologic,Tumor-derived exosomes,Epithe-lial mesenchymal transition