CDX2与胃肠道肿瘤

国际肿瘤学杂志››2021,Vol. 48››Issue (6): 374-376.doi:10.3760/cma.j.cn371439-20201118-00072

居欣月, 胡春梅, 赵月, 唐艳()

吉林大学第二医院肿瘤血液科,长春 130041

收稿日期:2020-11-18修回日期:2021-01-03出版日期:2021-06-08发布日期:2021-06-24
通讯作者:唐艳 E-mail:yanrose136@163.com
基金资助:
吉林省自然科学基金(20200201368JC)

CDX2 and gastrointestinal neoplasms

Ju Xinyue, Hu Chunmei, Zhao Yue, Tang Yan()

Department of Tumor Hematology, Second Hospital of Jilin University, Changchun 130041, China

Received:2020-11-18Revised:2021-01-03Online:2021-06-08Published:2021-06-24
Contact:Tang Yan E-mail:yanrose136@163.com
Supported by:
National Science Foundation of Jilin Province of China(20200201368JC)

摘要/Abstract

摘要：

尾型同源盒转录因子2(CDX2)是一种肠特异性核转录因子,主要表达于小肠和结直肠,在正常胃黏膜不表达。CDX2参与了胃肠道肿瘤的发生、发展、侵袭和转移,其表达状态与胃肠道肿瘤患者的临床病理特征及预后相关。深入研究CDX2参与肿瘤发生发展的相关机制及其与临床病理特征及预后的关系,有望为胃肠道肿瘤的诊断及治疗提供新的思路。

关键词:CDX2转录因子,消化系统肿瘤,肠化生

Abstract:

Caudal type homeobox transcription factor 2 (CDX2) is an enteric-specific nuclear transcription factor, which is mainly expressed in the small intestine and colorectum and not expressed in normal gastric mucosa. CDX2 is involved in the occurrence, development, invasion and metastasis of gastrointestinal tumors, and its expression state is related to the clinicopathological characteristics and prognosis of patients with gastrointestinal tumors. It is expected to provide a new idea for the diagnosis and treatment of gastrointestinal tumors by further studying the mechanism of CDX2 involvement in tumor genesis and development and its relationship with clinicopathological features and prognosis.

Key words:CDX2 transcription factor,Digestive system neoplasms,Intestinal metaplasia

居欣月, 胡春梅, 赵月, 唐艳. CDX2与胃肠道肿瘤[J]. 国际肿瘤学杂志, 2021, 48(6): 374-376.

Ju Xinyue, Hu Chunmei, Zhao Yue, Tang Yan. CDX2 and gastrointestinal neoplasms[J]. Journal of International Oncology, 2021, 48(6): 374-376.

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