国际肿瘤学杂志››2021,Vol. 48››Issue (9): 572-.doi:10.3760/cma.j.cn371439-20201201-00112

• 综述 •上一篇下一篇

三氧化二砷抗肝癌机制及其在肝癌治疗中的研究

杜佳航, 陈栋, 陈耀庭()

  1. 中山大学孙逸仙纪念医院介入放射科,广州 510120
  • 收稿日期:2020-12-01修回日期:2021-01-06出版日期:2021-09-08发布日期:2021-09-22
  • 通讯作者:陈耀庭 E-mail:chenyaot@mail.sysu.edu.cn

Research progress of arsenic trioxide in anti-liver cancer mechanism and treatment of hepatocellular carcinoma

Du Jiahang, Chen Dong, Chen Yaoting()

  1. Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • Received:2020-12-01Revised:2021-01-06Online:2021-09-08Published:2021-09-22
  • Contact:Chen Yaoting E-mail:chenyaot@mail.sysu.edu.cn

摘要:

三氧化二砷(ATO)参与肝癌细胞的多种生物学过程,包括肿瘤细胞凋亡诱导、增殖抑制、侵袭转移抑制和肿瘤干细胞抑制等。ATO在肝癌治疗中有多种方式,主要包括单药治疗、联合局部治疗、联合全身治疗等。进一步研究ATO抗癌机制及临床应用有望为肝癌治疗提供新的思路。

关键词:肝肿瘤,治疗应用,三氧化二砷

Abstract:

Arsenic trioxide (ATO) is involved in a variety of biological processes of hepatocellular carcinoma (HCC) cells, including apoptosis induction, proliferation inhibition, invasion and metastasis inhibition, and tumor stem cell inhibition. ATO has a variety of therapeutic approaches in the treatment of HCC, mainly including single drug therapy, combined local therapy, combined systemic therapy, and so on. Further research on the anti-cancer mechanism and clinical application of ATO is expected to provide new ideas for the treatment of liver cancer.

Key words:Liver neoplasms,Therapeutic uses,Arsenic trioxide