间隙连接蛋白43与肿瘤

摘要/Abstract

摘要：细胞间隙连接是一种特殊的蛋白质通道，间隙连接介导的细胞间信息交流对细胞生长、分化及组织稳态至关重要。间隙连接蛋白43（Cx43）是间隙连接蛋白家族成员之一，近年来研究发现Cx43基因表达异常易导致细胞间隙连接通讯功能缺陷，这与多种肿瘤的发生、转移及预后密切相关，Cx43有望成为肿瘤临床诊断和治疗的新靶点。

文晓荣，莫红梅，郭涛，丁梦婷. 间隙连接蛋白43与肿瘤[J]. 国际肿瘤学杂志, 2018, 45(1): 32-.

Wen Xiaorong*, Mo Hongmei, Guo Tao, Ding Mengting. Connexin 43 and tumors[J]. Journal of International Oncology, 2018, 45(1): 32-.

［1］ Grek CL, Rhett JM, Ghatnekar GS. Cardiac to cancer: connecting connexins to clinical opportunity［J］. FEBS Lett, 2014, 588(8): 13491364. DOI: 10.1016/j.febslet.2014.02.047. ［2］ Rhett JM, Fann SA, Yost MJ. Purinergic signaling in early inflammatory events of the foreign body response: modulating extracellular ATP as an enabling technology for engineered implants and tissues［J］. Tissue Eng Part B Rev, 2014, 20(5): 392402. DOI: 10.1089/ten.TEB.2013.0554. ［3］ Jin Z, Xu S, Yu H, et al. miR125b inhibits Connexin43 and promotes glioma growth［J］. Cell Mol Neurobiol, 2013, 33(8): 11431148. DOI: 10.1007/s1057101399801. ［4］ Ableser MJ, Penuela S, Lee J, et al. Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo［J］. J Biol Chem, 2014, 289(3): 15921603. DOI: 10.1074/jbc.M113.507228. ［5］ Chen R, Luan Y, Liu Z, et al. AR pathway is involved in the regulation of CX43 in prostate cancer［J］. Biomed Res Int, 2015, 2015: 514234. DOI: 10.1155/2015/514234. ［6］ Macdonald AI, Sun P, HernandezLopez H, et al. A functional interaction between the MAGUK protein hDIg and the gap junction protein connexin 43 in cervical tumour cells［J］. Biochem J, 2012, 446(1): 921. DOI: 10.1042/BJ20111144. ［7］ Sun P, Dong L, MacDonald AI, et al. HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells［J］. Viruses, 2015, 7(10): 52435256. DOI: 10.3390/v7102871. ［8］ Sulkowska U, Wincewicz A, KanczugaKoda L, et al. Eventual proapoptotic or antiapoptotic impact of aberrantly expressed Cx43 and Cx26 can depend on ERalpha overexpression in human endometrioid adenocarcinoma［J］. Gynecol Endocrinol, 2015, 31(8): 604608. DOI: 10.3109/09513590.2015.1017811. ［9］ Matharu G, Tucker O, Alderson D. Systematic review of intraperitoneal chemotherapy for gastric cancer［J］. Br J Surg, 2011, 98(9): 12251235. DOI: 10.1002/bjs.7586. ［10］ Tang B, Peng ZH, Yu PW, et al. Aberrant expression of Cx43 is associated with the peritoneal metastasis of gastric cancer and Cx43mediated gap junction enhances gastric cancer cell diapedesis from peritoneal mesothelium［J］. PLoS One, 2013, 8(9): e74527. DOI: 10.1371/journal.pone.0074527. ［11］ Fu Y, Shao ZM, He QZ, et al. HsamiRV206 represses the proliferation and invasion of breast cancer cells by targeting Cx43［J］. Eur Rev Med Pharmacol Sci, 2015, 19(11): 20912104. ［12］ Lamiche C, Clarhaut J, Strale PO, et al. The gap junction protein Cx43 is involved in the bonetargeted metastatic behaviour of human prostate cancer cells［J］. Clin Exp Metastasis, 2012, 29(2): 111122. DOI: 10.1007/s1058501194344. ［13］ Zhang A, Hitomi M, BarShain N, et al. Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration［J］. Oncotarget, 2015, 6(13): 1164011651. DOI: 10.18632/oncotarget.3449. ［14］ Qiu X, Cheng JC, Zhao J, et al. Transforming growth factorβ stimulates human ovarian cancer cell migration by upregulating connexin43 expression via Smad2/3 signaling［J］. Cell Signal, 2015, 27(10): 19561962. DOI: 10.1016/j.cellsig.2015.07.010. ［15］ Liu X, Cao K, Xu C, et al. GATA3 augmentation downregulates Connexin43 in helicobacter pylori associated gastric carcinogenesis［J］. Cancer Biol Ther, 2015, 16(6): 987996. DOI: 10.1080/15384047.2015.1030552. ［16］ Ming J, Zhou Y, Du J, et al. miR381 suppresses C/EBPαdependent Cx43 expression in breast cancer cells［J］. Biosci Rep, 2015, 35(6). pii: e00266. DOI: 10.1042/BSR20150167. ［17］ Brockmeyer P, Hemmerlein B, Jung K, et al. Connexin subtype expression during oral carcinogenesis: a pilot study in patients with oral squamous cell carcinoma［J］. Mol Clin Oncol, 2016, 4(2): 298302. DOI: 10.3892/mco.2015.685. ［18］ Brockmeyer P, Jung K, Perske C, et al. Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma［J］. Int J Oncol, 2014, 45(1): 273281. DOI: 10.3892/ijo.2014.2394. ［19］ Ismail R, Rashid R, Andrabi K, et al. Pathological implications of Cx43 downregulation in human colon cancer［J］. Asian Pac J Cancer Prev, 2014, 15(7): 29872991. ［20］曹建, 孙萍. Ⅱ期结肠癌的辅助化学治疗［J］. 国际肿瘤学杂志, 2013, 40(6): 463465. DOI: 10.3760/cma. j.issn.1673422X.2013.06.020. ［21］ Wang J, Dai Y, Huang Y, et al. Alltrans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions in vitro［J］. Med Oral Patol Oral Cir Bucal, 2013, 18(4): e569e577. ［22］ Forster T, Rausch V, Zhang Y, et al. Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43mediated gap junctional intercellular communication［J］. Oncotarget, 2014, 5(6): 16211634. DOI: 10.18632/oncotarget.1764. ［23］ Grek CL, Rhett JM, Bruce JS, et al. Targeting connexin 43 with αconnexin carboxylterminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1［J］. BMC Cancer, 2015, 15: 296. DOI: 10.1186/s1288501512296. ［24］ Ghosh S, Kumar A, Chandna S. Connexin43 downregulation in G2/M phase enriched tumour cells causes extensive lowdose hyperradiosensitivity (HRS) associated with mitochondrial apoptotic events［J］. Cancer Lett, 2015, 363(1): 4659. DOI: 10.1016/j.canlet.2015.03.046.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲.血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华.Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青.血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺.PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云.新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚.EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六.基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六.肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳.炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝.癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志.宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.

Connexin 43 and tumors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章15

编辑推荐

Metrics

本文评价