国际肿瘤学杂志››2018,Vol. 45››Issue (8): 548-551.doi:10.3760/cma.j.issn.1673-422X.2018.09.008
程思维,胡君,熊伍军
出版日期:
2018-09-08发布日期:
2018-11-15通讯作者:
熊伍军 E-mail:xiongwujun@126.comCheng Siwei, Hu Jun, Xiong Wujun
Online:
2018-09-08Published:
2018-11-15Contact:
Xiong Wujun E-mail:xiongwujun@126.com摘要:人溶质载体蛋白25家族是人溶质载体蛋白家族中的一个超家族,该家族成员通过跨线粒体膜转运各种溶质从而发挥作用。线粒体载体在转运底物的性质和大小、运输方式等方面差异很大,并且参与细胞的多种生理过程。越来越多的研究发现,该家族成员在肿瘤中异常表达,且部分成员在肿瘤的发生和发展中起到了一定的作用,如通过调节细胞代谢、死亡、增殖从而参与肿瘤发生、发展过程。
程思维,胡君,熊伍军. SLC25家族的基本特征及其在肿瘤中的作用[J]. 国际肿瘤学杂志, 2018, 45(8): 548-551.
Cheng Siwei, Hu Jun, Xiong Wujun. Essential characteristics and functions of SLC25 family in tumor[J]. Journal of International Oncology, 2018, 45(8): 548-551.
[1] Palmieri F. The mitochondrial transporter family SLC25: identification, properties and physiopathology[J]. Mol Aspects Med, 2013, 34(23): 465484. DOI: 10.1016/j.mam.2012.05.005. [2] Schlessinger A, Khuri N, Giacomini KM, et al. Molecular modeling and ligand docking for solute carrier (SLC) transporters[J]. Curr Top Med Chem, 2013, 13(7): 843856. [3] Wang YJ, Khan FI, Xu Q, et al. Recent studies of mitochondrial SLC25: integration of experimental and computational approaches[J]. Curr Protein Pept Sci, 2018, 19(5): 507522. DOI: 10.2174/1389203718666161108095052. [4] Palmieri F, Pierri CL, De Grassi A, et al. Evolution, structure and function of mitochondrial carriers: a review with new insights[J]. Plant J, 2011, 66(1): 161181. DOI: 10.1111/j.1365313X.2011.04516.x. [5] GutiérrezAguilar M, Baines CP. Physiological and pathological roles of mitochondrial SLC25 carriers[J]. Biochem J, 2013, 454(3): 371386. DOI: 10.1042/BJ20121753. [6] Poncet D, Pauleau AL, Szabadkai G, et al. Cytopathic effects of the cytomegalovirusencoded apoptosis inhibitory protein vMIA[J]. J Cell Biol, 2006, 174(7): 985996. DOI: 10.1083/jcb.200604069. [7] Wilkins HM, Marquardt K, Lash LH, et al. Bcl2 is a novel interacting partner for the 2oxoglutarate carrier and a key regulator of mitochondrial glutathione[J]. Free Radic Biol Med, 2012, 52(2): 410419. DOI: 10.1016/j.freeradbiomed.2011.10.495. [8] Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation[J]. Cell, 2011, 144(5): 646674. DOI: 10.1016/j.cell.2011.02.013. [9] Brix B, Mesters JR, Pellerin L, et al. Endothelial cellderived nitric oxide enhances aerobic glycolysis in astrocytes via HIF1αmediated target gene activation[J]. J Neurosci, 2012, 32(28): 97279735. DOI: 10.1523/JNEUROSCI.087912.2012. [10] Zhang H, Wang Q, Gu J, et al. Elevated mitochondrial SLC25A29 in cancer modulates metabolic status by increasing mitochondriaderived nitric oxide[J]. Oncogene, 2018, 37(19): 25452558. DOI: 10.1038/s413880180139x. [11] Baulies A, Montero J, Matías N, et al. The 2oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading[J]. Redox Biol, 2018, 14: 164177. DOI: 10.1016/j.redox.2017.08.022. [12] Traba J, Del Arco A, Duchen MR, et al. SCaMC1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADPmediated matrix Ca(2+) buffering[J]. Cell Death Differ, 2012, 19(4): 650660. DOI: 10.1038/cdd.2011.139. [13] Dalla Pozza E, Fiorini C, Dando I, et al. Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine[J]. Biochim Biophys Acta, 2012, 1823(10): 18561863. DOI: 10.1016/j.bbamcr.2012.06.007. [14] Sayeed A, Meng Z, Luciani G, et al. Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediategrade primary breast cancer[J]. Cell Death Dis, 2010, 1: e53. DOI: 10.1038/cddis.2010.30. [15] Wong CC, Qian Y, Li X, et al. SLC25A22 promotes proliferation and survival of colorectal cancer cells with KRAS mutations and xenograft tumor progression in mice via intracellular synthesis of aspartate[J]. Gastroenterology, 2016, 151(5): 945960.e6. DOI: 10.1053/j.gastro.2016.07.011. [16] Xie J, Zhu XY, Liu LM, et al. Solute carrier transporters: potential targets for digestive system neoplasms[J]. Cancer Manag Res, 2018, 10: 153166. DOI: 10.2147/CMAR.S152951. [17] CatalinaRodriguez O, Kolukula VK, Tomita Y, et al. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis[J]. Oncotarget, 2012, 3(10): 12201235. DOI: 10.18632/oncotarget.714. [18] Cheng L, Lu W, Kulkarni B, et al. Analysis of chemotherapy response programs in ovarian cancers by the nextgeneration sequencing technologies[J]. Gynecol Oncol, 2010, 117(2): 159169. DOI: 10.1016/j.ygyno.2010.01.041. [19] Favre C, Zhdanov A, Leahy M, et al. Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells[J]. Oncogene, 2010, 29(27): 39643976. DOI: 10.1038/onc.2010.146. [20] 吕依宣, 王晓娜, 吴金亮, 等. 线粒体二羧基载体蛋白SLC25A10对脑胶质瘤细胞增殖的影响及机制[J]. 上海交通大学学报(医学版), 2016, 36(11): 15811587, 1593. DOI: 10.3969/j.issn.16748115.2016.11.008. [21] 蔺媛媛. SLC25A10抑制肝癌凋亡的作用及机制研究[D]. 大连, 大连医科大学, 2017. [22] Tina E, Lindqvist BM, Gabrielson M, et al. The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2positive breast tumors[J]. BMC Cancer, 2012, 12: 350. DOI: 10.1186/1471240712350. [23] Lindqvist BM, Farkas SA, Wingren S, et al. DNA methylation pattern of the SLC25A43 gene in breast cancer[J]. Epigenetics, 2012, 7(3): 300306. DOI: 10.4161/epi.7.3.19064. [24] Prosén S, Eremo AG, Tsegai AD, et al. Decreased expression of the mitochondrial solute carrier SLC25A43 in basal cell carcinoma compared with healthy skin[J]. Oncol Lett, 2017, 14(2): 22182222. DOI: 10.3892/ol.2017.6452. [25] Santandreu FM, Valle A, Fernández de Mattos S, et al. Hydrogen peroxide regulates the mitochondrial content of uncoupling protein 5 in colon cancer cells[J]. Cell Physiol Biochem, 2009, 24(56): 379390. DOI: 10.1159/000257430. [26] Gonidi M, Athanassiadou AM, Patsouris E, et al. Mitochondrial UCP4 and bcl2 expression in imprints of breast carcinomas: relationship with DNA ploidy and classical prognostic factors[J]. Pathol, Res Pract, 2011, 207(6): 377382. DOI: 10.1016/j.prp.2011.03.007. [27] Chevrollier A, Loiseau D, Reynier P, et al. Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism[J]. Biochim Biophys Acta, 2011, 1807(6): 562567. DOI: 10.1016/j.bbabio.2010.10.008. [28] Wilting SM, de Wilde J, Meijer CJ, et al. Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer[J]. Genes Chromosomes Cancer, 2008, 47(10): 890905. DOI: 10.1002/gcc.20590. |
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