铁死亡作用机制及其与肿瘤的关系

国际肿瘤学杂志››2018,Vol. 45››Issue (10): 619-623.doi:10.3760/cma.j.issn.1673-422X.2018.10.009

铁死亡作用机制及其与肿瘤的关系

程霖,赵明峰

300192 天津医科大学一中心临床学院（程霖）；天津市第一中心医院血液科（赵明峰）

收稿日期:2018-04-08出版日期:2018-10-08发布日期:2018-12-21
通讯作者:赵明峰 E-mail:mingfengzhao@sina.com
基金资助:

国家自然科学基金（81400092）；天津市自然科学基金（17JCZDJC35800）

Mechanism of ferroptosis and its relationship with tumors

Cheng Lin, Zhao Mingfeng

First Central Clinic Medicine College of Tianjin Medical University, Tianjin 300192, China

Received:2018-04-08Online:2018-10-08Published:2018-12-21
Contact:Zhao Mingfeng E-mail:mingfengzhao@sina.com
Supported by:

National Natural Science Foundation of China (81400092); Tianjin Municipal Natural Science Foundation of China (17JCZDJC35800)

摘要/Abstract

摘要：铁死亡是近年来发现的一种新型细胞死亡方式，是铁依赖的脂质过氧化积累介导的细胞死亡，其在形态及生物化学上不同于凋亡、坏死等细胞死亡方式。铁死亡发生过程中伴随着谷胱甘肽的耗竭、谷胱甘肽过氧化物酶活性的下降以及大量脂质过氧化物的产生。研究发现，铁死亡可参与肿瘤的发生、进展，激活铁死亡通路中不同的调节位点可促进肿瘤细胞的死亡。因此，明确铁死亡通路及其调节肿瘤发展的相关机制可能为临床治疗肿瘤提供新的思路。

关键词:肿瘤,铁死亡,谷胱甘肽过氧化物酶,脂质过氧化作用

Abstract:Ferroptosis is a new type of cell death discovered in recent years. This form of irondependent cell death is morphologically and biochemically distinct from other cell death modalities, including apoptosis and necrosis. This process is accompanied by the depletion of glutathione, a decrease in glutathione peroxidase activity and the accumulation of lipid peroxidation products. Studies have found that ferroptosis can be involved in the occurrence and progression of tumor by activating different regulatory sites in the signaling pathways, which can promote tumor cell death. Therefore, to clarify ferroptosis pathway and its related mechanisms regulating tumor development may provide new ideas for clinical treatment of tumors.

Key words:Neoplasms,Ferroptosis,Glutathione peroxidase,Lipid peroxidation

程霖,赵明峰. 铁死亡作用机制及其与肿瘤的关系[J]. 国际肿瘤学杂志, 2018, 45(10): 619-623.

Cheng Lin, Zhao Mingfeng. Mechanism of ferroptosis and its relationship with tumors[J]. Journal of International Oncology, 2018, 45(10): 619-623.

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