细胞自噬与肿瘤的发生发展及治疗

摘要/Abstract

摘要：细胞自噬是细胞自我更新和维持内环境稳态的重要生理过程，在肿瘤的发生发展及治疗中均发挥“双重性”作用。自噬通过保持基因组的稳定性抑制肿瘤的发生，同时又是肿瘤细胞存活的保护性机制。自噬提高抗肿瘤治疗有效性的同时又与肿瘤耐药、放射抵抗有关。在不同情况下应用自噬调控药物有望提高肿瘤细胞的治疗敏感性。

关键词:自噬,肿瘤,药物疗法,放射疗法,靶向治疗

Abstract:Autophagy is a crucial physiological process for cellular selfrenewing and homeostasis, which plays a dual role in both tumorigenesis and antitumor treatment. It plays an antineoplastic role by maintaining genomic stability, as well as a protective role in tumorgenesis and progression. Autophagy improves the effectiveness of antitumor therapy, meanwhile, it involves in resistance of tumor cells to chemotherapy and irradiation. Using relevant autophagy regulators in different backgrounds is expected to become a new strategy for improving sensitivity of tumor cells to antitumor treatment.

Key words:Autophagy,Neoplasms,Drug therapy,Radiotherapy,Targeted therapy

王鑫，宋海平，王晔，孙宏权，马学真. 细胞自噬与肿瘤的发生发展及治疗[J]. 国际肿瘤学杂志, 2018, 45(12): 743-746.

Wang Xin, Song Haiping, Wang Ye, Sun Hongquan, Ma Xuezhen. Autophagy in tumorigenesis and cancer therapy[J]. Journal of International Oncology, 2018, 45(12): 743-746.

参考文献

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