lncRNA MEG3作为miR-21的ceRNA在恶性肿瘤中的作用

国际肿瘤学杂志››2020,Vol. 47››Issue (1): 35-38.doi:10.3760/cma.j.issn.1673-422X.2020.01.006

lncRNA MEG3作为miR-21的ceRNA在恶性肿瘤中的作用

李醒, 黄俊星()

南通大学第五附属医院(江苏省泰州市人民医院)肿瘤科 225300

收稿日期:2019-12-06修回日期:2019-12-13出版日期:2020-01-08发布日期:2020-03-22
通讯作者:黄俊星 E-mail:hjxtz@sina.cn
基金资助:
江苏省医学创新团队项目(CXTDA2017042)

Role of lncRNA MEG3 as ceRNA of miR-21 in cancer

Li Xing, Huang Junxing()

Department of Oncology, Fifth Hospital Affiliated to Nantong University (Taizhou People's Hospital of Jiangsu Province), Taizhou 225300, China

Received:2019-12-06Revised:2019-12-13Online:2020-01-08Published:2020-03-22
Contact:Huang Junxing E-mail:hjxtz@sina.cn
Supported by:
Medical Innovation Team Project of Jiangsu Province of China(CXTDA2017042)

摘要/Abstract

摘要：

长非编码RNA(lncRNA)-母系表达基因3(MEG3)和微小RNA-21(miR-21)是抑癌和致癌因子。竞争性内源RNA(ceRNA)假说为研究RNA之间的相互作用提供了新的策略。MEG3可作为miR-21的ceRNA在乳腺癌、宫颈癌、胃癌、肺癌、白血病等恶性肿瘤的发生、发展、增殖、转移以及药物耐药、预后中发挥重要作用。

关键词:肿瘤,RNA,长链非编码,竞争性内源RNA,母系表达基因3

Abstract:

Long non-coding RNA (lncRNA)-maternally expressed gene 3 (MEG3) and microRNA-21 (miR-21) have been widely recognized as tumor suppressor and promoter. The competing endogenous RNA (ceRNA) hypothesis provides a new strategy for studying the interaction of RNAs. In recent years, studies have shown that MEG3 can play an important role in the occurrence, development, proliferation, metastasis, drug resistance and prognosis of breast cancer, cervical cancer, gastric cancer, lung cancer, leukemia and other malignant tumors as the ceRNA of miR-21.

Key words:Neoplasms,RNA,long noncoding,Competing endogenous RNA,Maternally expressed gene 3

李醒, 黄俊星. lncRNA MEG3作为miR-21的ceRNA在恶性肿瘤中的作用[J]. 国际肿瘤学杂志, 2020, 47(1): 35-38.

Li Xing, Huang Junxing. Role of lncRNA MEG3 as ceRNA of miR-21 in cancer[J]. Journal of International Oncology, 2020, 47(1): 35-38.

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