血清炎性标志物对非小细胞肺癌免疫治疗的预测价值

摘要/Abstract

摘要：

免疫检查点抑制剂(ICI)不仅能在短时间内延长非小细胞肺癌(NSCLC)患者的生存时间,甚至还能对肿瘤实现持久应答。然而,ICI的疗效在不同类型NSCLC患者中存在显著异质性,目前仍缺乏普遍的生物标志物来预测ICI治疗的获益情况。炎症在肿瘤的发生发展中起一定作用,血清中多种炎性标志物也成为反映免疫状态的临床指标,如乳酸脱氢酶、C反应蛋白、血清中性粒细胞、淋巴细胞、血小板等指标。这些炎性标志物简单易得,与多种实体肿瘤的预后相关。

关键词:癌,非小细胞肺,免疫疗法,炎性标志物

Abstract:

Immune checkpoint inhibitors (ICIs) can not only prolong the survival time of patients with non-small cell lung cancer (NSCLC) in a short time, but also achieve a lasting response to the tumor. However, there has been significant heterogeneity in the efficacy of ICIs among patients with different types of NSCLC, and there has been still a lack of universal biomarkers to predict the benefit of ICIs treatment. Inflammation has played a definite role in the occurrence and development of tumors, and a variety of inflammatory markers in serum also have become clinical indicators reflecting immune status, such as lactate dehydrogenase, C-reactive protein, serum neutrophils, lymphocytes, platelets and other indicators. These inflammatory markers are easy to obtain and are associated with the prognosis of a variety of solid tumors.

Key words:Carcinoma,non-small-cell lung,Immunotherapy,Inflammatory markers

罗宏, 殷红, 胡广越, 陶红. 血清炎性标志物对非小细胞肺癌免疫治疗的预测价值[J]. 国际肿瘤学杂志, 2022, 49(3): 177-180.

Luo Hong, Yin Hong, Hu Guangyue, Tao Hong. Predictive value of serum inflammatory markers in immunotherapy of non-small cell lung cancer[J]. Journal of International Oncology, 2022, 49(3): 177-180.

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