化疗后骨髓抑制机制的研究进展

国际肿瘤学杂志››2023,Vol. 50››Issue (1): 33-36.doi:10.3760/cma.j.cn371439-20221005-00006

化疗后骨髓抑制机制的研究进展

孙琦¹, 李文倩²(), 解友邦², 周厚法¹

¹青海大学研究生院，西宁 810016
²青海省人民医院血液科，西宁 810000

收稿日期:2022-10-05修回日期:2022-11-26出版日期:2023-01-08发布日期:2023-03-16
通讯作者:李文倩 E-mail:lwq121616@163.com
基金资助:
国家血液系统疾病临床医学研究中心转化研究课题(2021WWB04);青海省血液系统疾病临床研究中心项目(2021-SF-136)

Research progress on the mechanism of bone marrow suppression after chemotherapy

Sun Qi¹, Li Wenqian²(), Xie Youbang², Zhou Houfa¹

¹Graduate School of Qinghai University， Xining 810016， China
²Department of Hematology， Qinghai Provincial People's Hospital， Xining 810000， China

Received:2022-10-05Revised:2022-11-26Online:2023-01-08Published:2023-03-16
Contact:Li Wenqian E-mail:lwq121616@163.com
Supported by:
Translational Research Grant of National Clinical Research Center for Hematological Diseases(2021WWB04);Project of Qinghai Provincial Clinical Research Center for Hematological Diseases(2021-SF-136)

摘要/Abstract

摘要：

化疗作为肿瘤的有效治疗手段，在清除肿瘤细胞的同时，对机体增殖旺盛的细胞尤其是造血细胞也产生明显的杀伤作用，造成化疗后骨髓抑制，影响化疗药物治疗效果及治疗周期。因此，从造血微环境损伤及造血干细胞衰老两方面入手，探讨化疗后骨髓抑制机制，可为肿瘤化疗后骨髓抑制的干预及管理提供新思路及理论支持。

关键词:造血干细胞,细胞衰老,骨髓抑制,化疗,造血微环境

Abstract:

As an effective treatment for cancer， chemotherapy not only removes tumor cells， but also produces obvious killing effects on proliferating cells， especially hematopoietic cells， resulting in bone marrow suppression after chemotherapy， and affecting the effects of chemotherapy drug treatment and treatment cycle. Therefore， starting from the aspects of hematopoietic microenvironment damage and hematopoietic stem cell aging， to explore the mechanism of myelosuppression after chemotherapy， which provides new ideas and theoretical support for the intervention and management of bone marrow suppression after cancer chemotherapy.

Key words:Hematopoietic stem cells,Cellular senescence,Myelosuppression,Chemotherapy,Hematopoietic microenvironment

孙琦, 李文倩, 解友邦, 周厚法. 化疗后骨髓抑制机制的研究进展[J]. 国际肿瘤学杂志, 2023, 50(1): 33-36.

Sun Qi, Li Wenqian, Xie Youbang, Zhou Houfa. Research progress on the mechanism of bone marrow suppression after chemotherapy[J]. Journal of International Oncology, 2023, 50(1): 33-36.

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