盐酸美金刚治疗放射性认知功能障碍及其与维生素联合应用的研究进展

国际肿瘤学杂志››2023,Vol. 50››Issue (10): 622-626.doi:10.3760/cma.j.cn371439-20230418-00118

盐酸美金刚治疗放射性认知功能障碍及其与维生素联合应用的研究进展

王瑾¹, 李若阳², 赵雪巍³, 李辉⁴, 周志国⁵, 赵静霞⁶()

¹河北医科大学研究生院，石家庄 050011
²河北医科大学第四医院乳腺中心，石家庄 050011
³河北医科大学第四医院药学部，石家庄 050011
⁴河北医科大学第四医院神经外科，石家庄 050011
⁵河北医科大学第四医院放疗科，石家庄 050011
⁶河北医科大学第四医院神经内科，石家庄 050011

收稿日期:2023-04-18修回日期:2023-07-02出版日期:2023-10-08发布日期:2023-11-08
通讯作者:赵静霞 E-mail:zjxlllzh@163.com
基金资助:
河北省财政厅2020年政府资助临床优秀人才培养项目（冀财预复〔2020〕397号）

Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins

Wang Jin¹, Li Ruoyang², Zhao Xuewei³, Li Hui⁴, Zhou Zhiguo⁵, Zhao Jingxia⁶()

¹Graduate School of Hebei Medical University，Shijiazhuang 050011， China
²Breast Center， Fourth Hospital of Hebei Medical University， Shijiazhuang 050011， China
³Department of Pharmacy， Fourth Hospital of Hebei Medical University， Shijiazhuang 050011， China
⁴Department of Neurosurgery， Fourth Hospital of Hebei Medical University， Shijiazhuang 050011， China
⁵Department of Radiotherapy， Fourth Hospital of Hebei Medical University， Shijiazhuang 050011， China
⁶Department of Neurology， Fourth Hospital of Hebei Medical University， Shijiazhuang 050011， China

Received:2023-04-18Revised:2023-07-02Online:2023-10-08Published:2023-11-08
Contact:Zhao Jingxia E-mail:zjxlllzh@163.com
Supported by:
Hebei Provincial Department of Finance 2020 Government Funded Clinical ExcellenceTraining Project（Ji Cai Yu Fu〔2020〕No. 397）

摘要/Abstract

摘要：

放射性认知功能障碍（RICD）起病隐匿，有效防治措施匮乏。盐酸美金刚作为经典治疗药物，疗效局限，寻求多靶点联合用药是必然趋势。近年来，维生素E、维生素D对认知功能的保护作用受到广泛认可。多项基础研究表明，维生素E能够通过保护神经元、降低盐酸美金刚引起的不良反应在联合用药中发挥作用；维生素D与盐酸美金刚因具有显著协同效应也已成为目前的研究热点。盐酸美金刚联合维生素治疗方案有望为RICD患者带来更多获益。

关键词:放射疗法,认知功能障碍,美金刚,维生素类

Abstract:

Radiation-induced cognitive dysfunction （RICD） has an insidious onset and there is a lack of effective prevention and treatment measures. The efficacy of memantine hydrochloride as a classical treatment drug is limited， and it is inevitable to seek multi-target combination drugs. In recent years， the protective effect of vitamin E and vitamin D on cognitive function has been widely recognized. Several basic studies have shown that vitamin E can play a role in the combination of medication by protecting neurons and reducing the adverse effects caused by memantine hydrochloride； Vitamin D and memantine hydrochloride have also become a hot topic of research due to their significant synergistic effects. The combination of memantine hydrochloride and vitamin therapy is expected to bring additional benefits to RICD patients.

Key words:Radiotherapy,Cognitive dysfunction,Memantine,Vitamins

王瑾, 李若阳, 赵雪巍, 李辉, 周志国, 赵静霞. 盐酸美金刚治疗放射性认知功能障碍及其与维生素联合应用的研究进展[J]. 国际肿瘤学杂志, 2023, 50(10): 622-626.

Wang Jin, Li Ruoyang, Zhao Xuewei, Li Hui, Zhou Zhiguo, Zhao Jingxia. Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins[J]. Journal of International Oncology, 2023, 50(10): 622-626.

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