EVI1在急性髓系白血病中的研究进展

国际肿瘤学杂志››2024,Vol. 51››Issue (7): 474-477.doi:10.3760/cma.j.cn371439-20231218-00078

EVI1在急性髓系白血病中的研究进展

吴市委, 裴康佳, 张东星, 秦占雨, 郭树霞()

河南中医药大学第五临床医学院（郑州人民医院）血液科，郑州 450000

收稿日期:2023-12-18修回日期:2024-03-27出版日期:2024-07-08发布日期:2024-08-14
通讯作者:郭树霞，Email：guosx118@126.com
基金资助:
河南省科技攻关项目(212102310786)

Advances in the study of EVI1 in acute myeloid leukemia

Wu Shiwei, Pei Kangjia, Zhang Dongxing, Qin Zhanyu, Guo Shuxia()

Department of Hematology， Fifth Clinical Medica College of Henan University of Chinese Medicine （People's Hospital of Zhengzhou）， Zhengzhou 450000， China

Received:2023-12-18Revised:2024-03-27Online:2024-07-08Published:2024-08-14
Contact:Guo Shuxia， Email：guosx118@126.com
Supported by:
Henan Provincial Program for Science and Technology Development(212102310786)

摘要/Abstract

摘要：

急性髓系白血病（AML）是血液系统常见的恶性疾病，伴EVI1高表达患者占成人AML的8%~10%。研究表明EVI1高表达在AML的治疗与预后中发挥重要作用。近些年来研究人员不断揭示EVI1的结构与作用，但其介导AML的机制尚未完全明确。系统探讨EVI1在AML中的作用可为EVI1高表达AML患者的精准化治疗提供有益参考。

关键词:髓系亲嗜性病毒整合位点1蛋白,白血病,髓样,急性,基因表达,治疗

Abstract:

Acute myeloid leukemia （AML） is a common malignant disease of the hematological system， with high EVI1 expression accounting for 8%-10% of adult AML. Studies have shown that high EVI1 expression plays an important role in the treatment and prognosis of AML. In recent years， researchers have continuously revealed the structure and role of EVI1， but its mechanism of mediating AML has not been fully clarified. Therefore， systematically exploring the role of EVI1 in AML may provide a useful reference for the precise treatment of AML patients with high EVI1 expression.

Key words:Myeloid ecotropic viral integration site 1 protein,Leukemia,myeloid,acute,Gene expression,Therapy

吴市委, 裴康佳, 张东星, 秦占雨, 郭树霞. EVI1在急性髓系白血病中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(7): 474-477.

Wu Shiwei, Pei Kangjia, Zhang Dongxing, Qin Zhanyu, Guo Shuxia. Advances in the study of EVI1 in acute myeloid leukemia[J]. Journal of International Oncology, 2024, 51(7): 474-477.

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