国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (5): 348-351.

• 综述 •上一篇下一篇

细胞因子诱导杀伤细胞的抗肿瘤机制及其应用研究

王春花，何义富，胡冰

  1. 合肥，安徽医科大学附属省立医院肿瘤化疗科
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:胡冰，E-mail: hubing@csco.org.cn E-mail:hubing@csco.org.cn

Anti-tumor mechanism of CIK cells and research

WANG Chun- hua，HE Yi-fu, HU Bing.

  1. Department of Chemotherapy, Affiliated Provincial Hospital, Anhui Medical Uniersity, Anhui 230001, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:HU Bing, E-mail: hubing@csco.org.cn E-mail:hubing@csco.org.cn

PDF

2299

被引次数

9

摘要：细胞因子诱导杀伤细胞（CIK）为自然杀伤（NK）细胞活性的T淋巴细胞，具有抗肿瘤活性。研究发现，CIK细胞通过分泌细胞毒颗粒及细胞因子、活化NKG2D受体、调节癌基因表达等发挥抗肿瘤作用。CIK不仅杀伤肿瘤细胞，而且可提高肿瘤患者的免疫力，改善生活质量。国内外研究显示CIK治疗无明显不良反应，是肿瘤治疗的一种全新模式，因此，可广泛应用于临床。

关键词:肿瘤,杀伤细胞,免疫疗法

Abstract:Cytokineinduced killer (CIK) cells are T lymphocytes which have natural killer cell activity and antitumor activity. It is found that CIK cells play an important role in killing tumor cells by secreting cytotoxic granules and cytokines, activating NKG2D receptor and regulating oncogene expression. CIK cells can not only kill the tumor cells, but also can improve immune system and the quality of life of patients. A large number of studies have shown that CIK treatment is a new mode of cancer treatment without obvious adverse reactions and can be widely applied in clinical treatment.

Key words:Neoplasms,Killer cells,Immunotherapy