国际肿瘤学杂志››2012,Vol. 39››Issue (5): 377-380.

• 综述 •上一篇下一篇

基底细胞样乳腺癌

李生兰,张清媛

  1. 哈尔滨医科大学附属第三医院内三科
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:张清媛, E-mail: zhma19650210@163.com E-mail:zhma19650210@163.com

Basal-like breast cancer

LI Sheng-lan, ZHANG Qing-yuan

  1. Department of Internal Medicine, Third Affiliated Hospital of Harbin Medicical University, Harbin 150080, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:ZHANG Qing-yuan, E-mail: zhma19650210@163.com E-mail:zhma19650210@163.com

摘要:基底细胞样乳腺癌(BLBC)是指具有基底细胞基因表型并且伴有不同程度地表达基底细胞角蛋白和(或)肌上皮标志物的乳腺癌,其具有独特的基因表型和形态特点。BLBC在年轻患者中常见,并且极易复发转移。大部分BLBC雌激素、孕激素受体及表皮生长因子受体2表达缺失,因此这种以三阴性为主的乳腺癌靶向治疗受到限制。

关键词:乳腺肿瘤,分子病理学,治疗

Abstract:Basal-like breast cancer (BLBC) is a basal cell phenotype and associated with different levels of expression in basal cell keratin and (or) myoepithelial markers in breast cancer, which has a unique genetic phenotype and morphological characteristics. BLBC is prevalent in young woman, and it is easy to relapse and metastasis. Additionally, most BLBC has expression loss of estrogen receptor and progesterone receptor and human epidermal growth factor receptor 2, which limits the targeted therapeutic options for these predominantly triple-negative breast cancers.

Key words:Breast neoplasms,Molecular pathology,Therapy