国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (5): 395-400.

• 论著 •上一篇

细胞周期蛋白D1基因G870A 多态性与结直肠癌易感性的系统评价

邹喜,张纬建,洪金省,刘锋,蔡传书,王培荣,陈德钦

  1. 福州，福建医科大学第一临床医学院放疗科（邹喜、张纬建、洪金省、刘锋、蔡传书、王培荣）,公共卫生学院（陈德钦）
  • 出版日期:2012-05-08发布日期:2012-05-02
  • 通讯作者:张纬建，E-mail: zwj9090@126.com E-mail:zwj9090@126.com

Cyclin D1 G870A polymorphism and the risk of colorectal cancer: a systematic review

ZOU Xi*, ZHANG Wei-jian, HONG Jin-sheng, LIU Feng, CAI Chuan-shu, WANG Pei-rong, CHEN De-qin

  1. *Department of Radiotherapy, First Clinical Medical College of Fujian Medical University, Fuzhou 350004, China
  • Online:2012-05-08Published:2012-05-02
  • Contact:ZHANG Wei-jian, E-mail: zwj9090@126.com E-mail:zwj9090@126.com

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1475

被引次数

6

摘要：目的 综合评价细胞周期蛋白D1(Cyclin D1) 基因G870A多态性与结直肠癌易感性的关系.方法通过CNKI、PubMed、EMCC等数据库检索文献,获得有关Cyclin D1基因G870A多态性与结直肠癌危险性关系的研究结果,并通过Meta分析进行系统评价。所有文献均采用病例对照研究或者巢式病例对照研究,以OR值为效应指标, 基因型在对照群体中的分布均符合HardyWeinberg 遗传平衡定律，对文献进行评价筛选、异质性检验。本次Meta分析共纳入23项研究,累计病例6 344例,对照9 018例，利用RevMan5.0对各研究原始结果进行统计处理, 对突变纯合子AA 和杂合子GA 基因型与纯合基因型GG 进行比较，并计算合并OR值及其95%可信区间(CI）。结果 AA和GA与GG基因型在病例组与健康对照组之间差异有统计学意义，OR= 1.10（95%CI：1.01～1.19, P=0.02）；按不同人群进行分层分析，亚洲人群OR= 1.11（95%CI：0.98～1.26, P=0.11），美洲人群OR= 1.13（95%CI：0.97~1.32,P=0.12)，欧洲人群OR= 1.06（95%CI：0.89～1.25, P=0.52），大洋洲人群OR= 1.05（95%CI：0.80～1.38, P=0.73）；按不同对照进行分组分析，医院基础OR= 1.07（95%CI：0.95～1.20, P=0.28），人群基础OR= 1.13（95%CI：1.01~1.26, P=0.04）。结论 Cyclin D1基因G870A 多态性与结直肠癌易感性总体分析在统计学上具有相关性，按不同人群进行分组分析，都不支持具有相关性；按不同对照进行分组分析，以医院基础不具有相关性，以人群为基础具有相关性。

关键词:结直肠肿瘤,细胞周期蛋白D1,G870A多态性,Meta分析

Abstract:Objective To evaluate the association between Cyclin D1 G870A polymorphism and risk of colorectal cancer. Methods Extensive searches of relevant studies on datebase like PubMed, EMCC and CNKI were performed. Case control studies involving unrelated subjects and genotype frequencies in control group consistent with HardyWeinberg equilibrium were included for the metaanalysis. Twentythree casecontrol studies with 6 344 cases and 9 018 controls were analyzed by the fixedeffect or randomeffect metaanalysis method. The metaanalysis was applied with RevMan 5.0 software for heterogeneity test. AA and GA were compared with those with GG genotype. Pooled ORvalue and 95% confidence interval(CI) were calculated. Results There were statistical differences between AA & GA and GG. The pooled ORvalue was 1.10 (95%CI：1.01~1.19, P=0.02). The values were analyzed hierarchically according to different populations. The pooled OR value of Asian was 1.11（95%CI：0.98~1.26, P=0.11）. The pooled OR value of American was 1.13（95%CI：0.97~1.32, P=0.12）. The pooled ORvalue of European was 1.06（95%CI：0.89~1.25, P=0.52）. The pooled ORvalue of Oceanian was 1.05（95%CI：0.80~1.38, P=0.73）. The values were analyzed hierarchically according to the comparison basis. The pooled ORvalue of hospitalbased was 1.07（95%CI：0.95~1.20,P=0.28）. The pooled ORvalue of populationbased was 1.13（95%CI：1.01~1.26, P=0.04）. Conclusion The Cyclin D1 G870A polymorphism is correlated with the susceptibility of colorectal cancer risk at the aggregate level analysis. Analysis by different methods: according to different populations, every group don′t support the correlation. According to comparison basis, there has no correlation in hospitalbased group, but there has correlation in populationbased group.

Key words:Colorectal neoplasms,Cyclin D1,G870A polymorphism,Meta anaiysis