结直肠癌多药耐药逆转的研究进展

摘要/Abstract

摘要：

结直肠癌的化疗疗效和预后受到多药耐药现象的影响。针对多药耐药发生的常见环节，包括ATP结合盒蛋白、代谢酶、细胞凋亡基因、信号通路及遗传物质等，目前已有诸多研究尝试研发相对应的抑制剂以克服耐药问题，其中P-糖蛋白抑制剂和破坏DNA复制修复药物的开发较为成熟。开发新的耐药靶点抑制剂，或探究已有耐药靶点抑制剂与传统治疗方案联用，是克服结直肠癌耐药的突破点。

关键词:结直肠肿瘤,抗药性，肿瘤

Abstract:

Multidrug resistance impacts negatively upon the curative effect of chemotherapy and prognosis in colorectal cancer. There is a growing body of studies trying to develop drugs to overcome multidrug resistance against its common targets， including ATP-binding cassette proteins， metabolic enzymes， apoptotic genes， signaling pathways and genetic material， among which P-glycoprotein inhibitors and drugs disrupting DNA are deeply developed. Developing new inhibitors or combining existing inhibitors with conventional treatment are hopeful ways to overcome multidrug resistance in colorectal cancer.

Key words:Colorectal neoplasms,Drug resistance， neoplasm

王熙, 吴川清. 结直肠癌多药耐药逆转的研究进展[J]. 国际肿瘤学杂志, 2023, 50(1): 42-46.

Wang Xi, Wu Chuanqing. Research progress in reversing multidrug resistance in colorectal cancer[J]. Journal of International Oncology, 2023, 50(1): 42-46.

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