国际肿瘤学杂志››2012,Vol. 39››Issue (6): 425-428.

• 综述 •上一篇下一篇

血清自身抗体在肿瘤早期诊断中的作用

彭裕辉,许镒洧

  1. 汕头大学医学院附属肿瘤医院检验科
  • 出版日期:2012-06-08发布日期:2012-06-25
  • 通讯作者:许镒洧,E-mail: yiwei512@126.com E-mail:yiwei512@126.com

Effect of serum autoantibodies in the early diagnosis of cancer

PENG Yu-hui, XU Yi-wei

  1. Department of Clinical Laboratory Science, Affiliated Tumor Hospital of Shantou University Medical College, Shantou 515041, China
  • Online:2012-06-08Published:2012-06-25
  • Contact:XU Yi-wei, E-mail: yiwei512@126.com E-mail:yiwei512@126.com

摘要:常用的肿瘤检测标志物敏感性低,特异性差,无法实现早期诊断目的,而肿瘤相关抗原的自身抗体能在肿瘤无症状阶段被检测到,因此可作为肿瘤早期诊断的生物标志物。由于自身抗体能在血清中检测到,所以能作为一种方便的非侵入性方法对肿瘤进行筛选。具有高度敏感性和特异性的自身抗体谱的发现,将有助于改善对肿瘤患者的诊断和预测。

关键词:自身抗体,肿瘤,早期诊断

Abstract:At present, the commonly used tumor markers, with low sensitivity and low specificity, can't achieve the purpose of early diagnosis. However, autoantibodies against tumorassociated antigens have been detected in the asymptomatic stage of cancer and thus can serve as biomarkers for early cancer diagnosis. Moreover, due to autoantibodies are found in sera, they can be screened easily using a noninvasive approach. The discovery of panels of autoantibodies with high sensitivity and specificity will help to improve the diagnostic and prognostic for the patients with cancer.

Key words:Autoantibodies,Neoplasms,Early diagnosis