国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (7): 483-485.

• 综述 •下一篇

肿瘤多药耐药与细胞凋亡逃逸

孙菲,卿晨

  1. 昆明医学院药学院暨云南省天然药物药理重点实验室
  • 出版日期:2012-08-06发布日期:2012-08-06
  • 通讯作者:卿晨，E-mail:qingchenhh@yeah.net E-mail:E-mail:qingchenhh@yeah.net

Tumor multidrug resistance and apoptosis evasion

SUN Fei, QING Chen

  1. School of Pharmacy ＆ Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical College, Kunming 650500, China
  • Online:2012-08-06Published:2012-08-06
  • Contact:QING Chen, E-mail: qingchenhh@yeah.net E-mail:E-mail:qingchenhh@yeah.net

PDF

2096

被引次数

6

摘要：多数抗肿瘤药物通过诱导细胞凋亡而发挥作用，如果发生凋亡逃逸即细胞抗凋亡能力提高如抗凋亡基因过表达或促凋亡基因丢失等，可能导致肿瘤细胞产生耐药性。研究表明，细胞凋亡逃逸与肿瘤多药耐药(MDR)的形成具有重要联系。

关键词:抗药性,肿瘤,细胞凋亡,肿瘤逃逸

Abstract:Most anticancer drugs inhibit tumor cell growth by inducing apoptosis. Apoptosis-evasion, also enhancement of antiapoptosis ability (e.g. anti-apoptosis related genes over-expression or pro-apoptotic related genes loss, etc.) may lead to tumor cell multidrug resistance. Many researches show that apoptosis-evasion is one of the important factors resulting in tumor multidrug resistance.

Key words:Drug resistance,neoplasm,Apoptosis,Tumor escape