国际肿瘤学杂志››2012,Vol. 39››Issue (8): 566-569.

• 综述 •上一篇下一篇

微小RNA相关调控通路与肿瘤发生发展

李俊,鹿欣

  1. 上海,复旦大学附属妇产科医院妇科
  • 出版日期:2012-08-29发布日期:2012-08-29
  • 通讯作者:鹿欣,E-mail,xinlu98@yahoo.com E-mail:xinlu98@yahoo.com
  • 基金资助:

    国家自然科学基金资助项目(81172456)

MicroRNA-related pathways and tumorigenesis and tumor development

LI Jun, LU Xin

  1. Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
  • Online:2012-08-29Published:2012-08-29
  • Contact:LU Xin, E-mail: xinlu98@yahoo.com E-mail:xinlu98@yahoo.com

摘要:研究表明,微小RNA(miRNA)在多数肿瘤中存在异常表达。miRNA相关调控通路,包括miRNA与蛋白编码基因及miRNA与长链非编码RNA(lncRNA)间的相互调控,与肿瘤的发生发展密切相关。miRNA有望成为临床肿瘤治疗的新靶点。

关键词:微RNAs,肿瘤形成过程

Abstract:Aberrant microRNA(miRNA) expression has been found in most of human cancers. miRNA-related regulation pathways, including the interaction between miRNA and proteincoding gene and the interaction between miRNA and lncRNA, have been shown correlated with the initiation and progression of human cancers. miRNA might be a therapeutic target in the treatment of malignancies.

Key words:MicroRNAs,Neoplastic processes