miR-34家族用于胃癌治疗的分子基础及临床前景

摘要/Abstract

摘要：

miR-34家族在胃癌中起着重要作用，与正常胃黏膜组织相比，在胃癌细胞株和胃癌组织中检测到miR-34家族的失活或表达减低，表明其与胃癌的发生发展有关。研究表明miR-34通过调节IGF2BP3、生存素、Bcl-2以及上皮-间质转化相关通路，在抑制胃癌进展中发挥关键作用，可见miR-34是胃癌治疗的重要靶点。临床治疗方面，miR-34不仅被证实具有放化疗增敏性，并且在肿瘤临床试验中取得了不错的疗效。随着靶向胃癌的miR-34载体出现，使其用于胃癌治疗成为可能。深入了解miR-34用于胃癌治疗的分子基础及临床疗效，有助于评估miR-34家族作为胃癌治疗新靶点的潜力。

关键词:胃肿瘤,微RNAs,miR-34,上皮-间质转化

Abstract:

The miR-34 family plays an important role in gastric cancer， and the inactivation or reduced expression of the miR-34 family is detected in gastric cancer cell lines and gastric cancer tissues compared with normal gastric mucosa tissues， indicating it is associated with the occurrence and development of gastric cancer. Studies have shown that miR-34 plays a key role in inhibiting gastric cancer progression by regulating IGF2BP3， survivin， Bcl-2 and epithelial-mesenchymal transition-related pathway， indicating that miR-34 is an important target for gastric cancer treatment. In terms of clinical treatment， miR-34 has not only been proved to have radiochemotherapy sensitization， but also achieved good curative effect in tumor clinical trials. With the emergence of miR-34 vectors targeting gastric cancer， it is possible to use it for gastric cancer treatment. Deep understanding of the molecular basis and clinical efficacy of miR-34 for gastric cancer treatment can help to evaluate the potential of the miR-34 family as a new therapeutic target for gastric cancer.

Key words:Gastric neoplasms,MicroRNAs,miR-34,Epithelial-mesenchymal transition

井文君, 赵文文, 冯青青, 赵文飞, 赵丽丽, 张雪, 魏红梅. miR-34家族用于胃癌治疗的分子基础及临床前景[J]. 国际肿瘤学杂志, 2022, 49(11): 681-686.

Jing Wenjun, Zhao Wenwen, Feng Qingqing, Zhao Wenfei, Zhao Lili, Zhang Xue, Wei Hongmei. Molecular basis and clinical prospect of the miR-34 family for the treatment of gastric cancer[J]. Journal of International Oncology, 2022, 49(11): 681-686.

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