国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (10): 729-731.

• 综述 •上一篇下一篇

微小RNA与肿瘤血管生成

肖磊,迟玉龙,丁文元,刘运来

  1. 400038 重庆市第三军医大学学员一队（肖磊、迟玉龙、丁文元），组胚教研室（刘运来）
  • 出版日期:2012-10-31发布日期:2012-10-31
  • 通讯作者:刘运来，E-mail: fooljohn2010@hotmail.com E-mail:fooljohn2010@hotmail.com
  • 基金资助:

    重庆市自然科学基金资助项目（CSTC,2010BB5191）

microRNA and tumor angiogenesis

XIAO Lei, CHI Yu-Long, DING Wen-Yuan, LIU Yun-Lai

  1. First Student Troop, Third Military Medical University, Chongqing 400038, China
  • Online:2012-10-31Published:2012-10-31
  • Contact:LIU Yun-lai, E-mail: fooljohn2010@hotmail.com E-mail:fooljohn2010@hotmail.com

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被引次数

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摘要：肿瘤细胞表达的相关微小RNA（miRNA）通过调控血管内皮生长因子（VEGF）的表达，影响肿瘤血管生成，而血管生成在肿瘤的生长发展等过程中起着十分重要的作用。因此深入研究miRNA的功能将为抑制肿瘤血管生成提供更有效的靶点，为肿瘤的临床诊治提供更可靠的依据。

关键词:微RNAs,血管内皮生长因子A,肿瘤,新生血管化

Abstract:Angiogenesis plays an important role in the development process of tumor, and related microRNA(miRNA) in tumor cells can regulate tumor angiogenesis via the pathway of vascular endothelial growth factor(VEGF). Therefore, the further study of miRNA function will provide more effective targets to inhibit tumor angiogenesis, and provide more reliable basis for the clinical diagnosis and treatment of tumor.

Key words:MicroRNAs,Vascular endothelial growth factor A,Neoplasms,Neovascularization