国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (10): 772-775.

• 综述 •上一篇下一篇

基质金属蛋白酶-9对结直肠癌侵袭转移的影响

陈星竹,周利红,李琦

  1. 200062 上海中医药大学附属普陀医院肿瘤科 上海中医药大学中西医结合肿瘤介入研究所
  • 出版日期:2012-10-31发布日期:2012-10-31
  • 通讯作者:李琦，E-mail: lzwf@hotmail.com E-mail:lzwf@hotmail.com
  • 基金资助:

    国家自然科学基金资助项目（30873404）；上海市科委基金资助项目（10ZR1427400,10140902600）;上海市卫生系统优秀学科带头人计划项目（XBR2011061）；上海市教委科研创新基金资助项目（09YZ132，12YZ058）；上海市重点学科基金资助项目（S30302）

Matrix metalloproteinase-9 in the invasion and metastasis of colorectal cancer

CHEN Xing-Zhu, ZHOU Li-Hong, LI Qi

  1. Putuo Hospital and Interventional Oncology Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
  • Online:2012-10-31Published:2012-10-31
  • Contact:LI Qi, E-mail: lzwf@hotmail.com E-mail:lzwf@hotmail.com

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被引次数

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摘要：基质金属蛋白酶-9（MMP-9）是结直肠癌发生发展的重要促进基因，能够诱导结直肠癌细胞增殖、血管新生和肿瘤浸润，导致结直肠癌的侵袭转移。MMP-9对结直肠癌侵袭转移的影响既可独自完成又可与其他基因联合完成，是结直肠癌晚期转移的重要蛋白酶。

关键词:基质金属蛋白酶-9,结直肠肿瘤,肿瘤侵润,肿瘤转移

Abstract:Matrix metalloproteinases-9(MMP-9) is an important gene in colorectal cancer occurrence and development. MMP-9 can induce cell proliferation, angiogenesis and neoplasm infiltration, and then leads to colorectal cancer invasion and metastasis. MMP-9 can not only play the role individually in colorectal cancer invasion and migration, but also can cooperate with other genes. MMP-9 is a key protease in terminal metastasis of colorectal cancer.

Key words:Matrix metalloproteinases-9,Colorectal neoplasms,Neoplasm invasiveness,Neoplasm metastasis