国际肿瘤学杂志

国际肿瘤学杂志››2012,Vol. 39››Issue (12): 889-892.

• 综述 •上一篇下一篇

缺氧诱导因子1α与肿瘤

王瑞, 廖盛涛, 刘运来

  1. 400038重庆市第三军医大学学员旅七队（王瑞、廖盛涛）,组胚教研室（刘运来）
  • 出版日期:2012-12-08发布日期:2012-11-15
  • 通讯作者:刘运来，E-mail: fooljohn2010@hotmail.com E-mail:fooljohn2010@hotmail.com
  • 基金资助:

    重庆市自然科学基金资助项目（2010BB5191）

Hypoxia inducible factor-1 and tumor

WANG Rui, LIAO Sheng-Tao, LIU Yun-Lai

  1. Company 7 of Student Brigade, Third Military Medical University, Chongqing 400038, China
  • Online:2012-12-08Published:2012-11-15
  • Contact:Corresponding author： LIU Yun-lai, E-mail: fooljohn2010@hotmail.com E-mail:fooljohn2010@hotmail.com

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摘要：缺氧诱导因子1（HIF-1）通常在肿瘤中呈现高表达，对肿瘤的生长有促进作用。HIF-1因子与肿瘤病情、诊断和预后相关。因此，可将HIF-1因子作为肿瘤治疗的重要靶点，从转录、转录后和靶点水平提高治疗效率，延长患者的生存。

关键词:肿瘤,缺氧诱导因子1,诊断,治疗

Abstract:Hypoxia inducible factor-1(HIF-1) is usually highly expressed in tumor cells, and can promote tumor growth. HIF-1 is correlated with tumor condition, the diagnosis and the prognosis. Therefore, HIF-1 can be used for tumor treatment in the level of transcriprion, pro-transcriprion and target. It is possible to improve the treatment efficiency, and to lengthen patients lifespan.

Key words:Neoplasms,Hypoxia-inducible factor 1,Diagnosis,Therapy