国际肿瘤学杂志››2013,Vol. 40››Issue (1): 3-5.

• 综述 •下一篇

LATS2基因与肿瘤

章艳茹, 于珍, 邱录贵

  1. 300020天津,中国医学科学院血液病医院血液学研究所
  • 出版日期:2013-01-08发布日期:2013-01-15
  • 通讯作者:于珍,E-mail:yuyuzhen2003@yahoo.com.cn E-mail:yuyuzhen2003@yahoo.com.cn
  • 基金资助:

    国家科技支撑计划(2008BAI61B01)国家科技重大专项(2011ZX09302-007-04)天津市科技计划项目(09ZCZDSF03800)

LATS2 gene and tumor

ZHANG Yan-Ru, YU Zhen, QIU Lu-Gui

  1. Institute of Hematology ,Blood Diseases Hospital , Chinese Academy of Medical Sciences , Tianjin 300020, China
  • Online:2013-01-08Published:2013-01-15
  • Contact:Corresponding author: YU zhen, E-mail: yuyuzhen2003@yahoo.com.cn E-mail:yuyuzhen2003@yahoo.com.cn

摘要:LATS2基因为LATS肿瘤抑制家族成员,通过Hippo通路、p53 基因和Ras-ERK等信号途径在调节人类细胞周期和肿瘤的发生发展中起重要作用。一旦LATS2在细胞表达异常,可能导致肿瘤的发生。

关键词:肿瘤,信号转导,基因表达

Abstract:LATS2 gene, as one homolog of LATS tumor suppressor family, plays an important role in the control of cell cycles and tumor development through Hippo pathway, p53 gene and Ras-ERK signal transduction. Once an aberrant expression of LATS2 in cell to happen, it may lead to the tumor occurrence.

Key words:Neoplasms,Signal transduction,Gene expression