国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (7): 483-485.

• 综述 •下一篇

肥大细胞与肿瘤血管生成的研究进展

曹莉,李维,邓凡

  1. 510515 广东广州南方医科大学细胞生物学教研室
  • 出版日期:2013-07-08发布日期:2013-07-08
  • 通讯作者:邓凡, E-mail:fandeng@smu.edu.cn E-mail:fandeng@smu.edu.cn
  • 基金资助:

    国家自然科学基金（30973014，81272852）

Mast cells and tumor angiogenesis

CAO Li, LI Wei, DENG Fan-

  1. Department of Cell Biology, Southern Medical University, Guangzhou 510515, China
  • Online:2013-07-08Published:2013-07-08
  • Contact:DENG Fan E-mail:fandeng@smu.edu.cn

PDF

1556

摘要：肥大细胞（MC）是起源于骨髓，定居于组织的重要功能的免疫细胞。肿瘤可以通过干细胞因子（SCF）及其在肥大细胞上的受体c-kit来介导对MC的募集。新生血管为肿瘤提供充足的营养与氧气，为肿瘤生长所必需。MC在肿瘤部位的数量和分布与肿瘤的生长、血管新生密切相关。MC可以通过释放血管生成因子介导血管新生，促进肿瘤的进展。

关键词:肥大细胞,肿瘤,新生血管化,病理性

Abstract:Mast cells (MCs) are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor-derived stem cell fact MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can or (SCF) and its receptor c-kit on MCs. Neovascularization is necessary for the tumor growth by providing plenty of nutrients and oxygen. The numbers and distributions of mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors.

Key words:Mast cells,Neoplasms,Neovascularization, pathologic