国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (8): 608-611.

• 综述 •上一篇下一篇

肝细胞肝癌上皮间质转化的相关分子机制

叶英楠, 王越, 王扬等

  1. 300060天津医科大学附属肿瘤医院 天津市“肿瘤防治”重点实验室
  • 出版日期:2013-08-08发布日期:2013-08-15
  • 通讯作者:于津浦，E-mail: jinpu_yu@hotmail.com E-mail:jinpu_yu@hotmail.com
  • 基金资助:

    国家重点基础研究发展计划（2012CB933304）；国家自然科学基金（81272360）

Molecular mechanisms of epithelial-mesenchymal transition in hepatocellular carcinoma

YE Ying-Nan, WANG Yue, WANG Yang, et al

  1. Key Laboratory of Cancer Prevention and Therapy, Tianjin CancerInstituteand Hospital, Tianjin Medical University, Tianjin 300060, China
  • Online:2013-08-08Published:2013-08-15
  • Contact:Corresponding author：YU Jin-pu，E-mail: jinpu_yu@hotmail.com E-mail:jinpu_yu@hotmail.com

PDF

1894

被引次数

6

摘要：侵袭和转移是造成肝细胞肝癌(HCC)预后不良的重要因素。近年来，HCC上皮间质转化（EMT）已经被认为是HCC侵袭、转移的关键细胞学基础。尽管引起和维持EMT的分子机制并没有被完全阐明，但是转化生长因子-β(TGF-β)、磷脂酰肌醇3激酶（phosphatidyl inositol 3-kinase,PI3K）/蛋白激酶B（AKT）、细胞核转录因子-κB (NF-κB)、Wnt/β-连接素（β-catenin） 等细胞信号通路在EMT过程中的所起到的重要作用已经被证实。上述通路通过调控EMT过程直接或间接影响HCC的预后，这也为HCC的新型靶向药物的研究提供了分子基础。

关键词:癌,肝细胞,细胞转化,肿瘤,转化生长因子β

Abstract:The poorprognosisof hepatocellular carcinoma (HCC) is strongly associated with invasion and metastasis. Recently, theepithelial-mesenchymal transition(EMT) has beenconfirmed to be the cytologicalfoundationof invasion and metastasis. Yet, the molecularmechanismof inducing andmaintaining EMT has not been expounded completely. However,it has been demonstrated that transforming growth factor-β(TGF-β), phosphatidyl inositol 3-kinase/ protein kinase B( PI3K/AKT),nuclear factor-κB(NF-κB),Wnt/β-catenin signaling pathways play pivotal roles in the initiation and development of EMT.These signalingpathways can affect theprognosisof HCC by regulating EMT. From a drug development perspective, these signal pathways are potential and attractive targets for HCC treatment.

Key words:Carcinoma, hepatocellular,Cell transformation, neoplastic,Transforming growth factor beta