国际肿瘤学杂志

国际肿瘤学杂志››2013,Vol. 40››Issue (8): 652-655.

• 综述 •上一篇下一篇

低氧诱导因子-1及转化生长因子-β与肿瘤

高超, 冯向营

  1. 116021大连大学附属新华医院神经内科

  • 出版日期:2013-09-08发布日期:2013-09-16
  • 通讯作者:冯向营，E-mail: daiyue315@126. com E-mail:daiyue315@126. com

Hypoxia-inducible factor-1 and transforming growth factor-β in tumor

GAO Chao, FENG Xiang-Ying

  1. Department of Neurology, Xinhua Hospital , Dalian University , Dalian 116021, China

  • Online:2013-09-08Published:2013-09-16
  • Contact:Corresponding author: FENG Xiang-ying, E-mail: daiyue315@126.com E-mail:daiyue315@126. com

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摘要：低氧诱导因子-1（HIF-1）是最重要的低氧信号传递因子，普遍存在于大多数实体肿瘤。体内外实验证明HIF-1通过调节转化生长因子β（TGF-β）的表达水平，协同TGF-β发挥促肿瘤作用，进而影响肿瘤的发展及预后。

关键词:低氧诱导因子-1,转化生长因子-β,肿瘤,血管内皮生长因子

Abstract:Hypoxia-inducible factor-1 (HIF-1) is one of the most important hypoxia signal transmission factor, and it has been observed in many human tumors. HIF-1 could play a role of promoting tumor by regulating the expression level of transforming growth factor-β in vivo and in vitro, and then affecting the development and prognosis of tumor.

Key words:Hypoxia-inducible factor-1,Transforming growth factor-β,Neoplasms,Vascular endothelial growth factors