国际肿瘤学杂志››2013,Vol. 40››Issue (10): 736-738.

• 综述 •上一篇下一篇

细胞周期相关激酶的肿瘤机制

谢旭, 田野, 谭广

  1. 116011大连医科大学附属第一医院肝胆外科
  • 出版日期:2013-10-08发布日期:2013-09-23
  • 通讯作者:谭广,E-mail:tanguang009@sina.com E-mail:tanguang009@sina.com

Carcinogenesis of cell cycle-related kinase

XIE Xu, TIAN Ye, TAN Guang

  1. DepartmentofHepatobiliarySurgery, First Affiliated Hospital of Dalian Medical University , Dalian 116011, china
  • Online:2013-10-08Published:2013-09-23
  • Contact:TAN Guang, E-mail: tanguang009@sina.com E-mail:tanguang009@sina.com

摘要:细胞周期相关激酶(CCRK)作为一种新发现的细胞周期依赖激酶活化激酶,主要参与细胞周期的调控。相关研究证实CCRK在多种肿瘤细胞中均有过表达,且与患者不良预后密切相关,提示CCRK参与了肿瘤的发生发展过程。

关键词:基因表达调控,肿瘤,细胞周期蛋白依赖激酶,细胞周期

Abstract:Cell cycle-related kinase (CCRK) as a novel CDK-activating kinase plays a significant role in cell cycle regulation. Related studies confirm that CCRK is overexpressedin varioustumors, and is associated withpoor prognosis of the patients, which indicates that CCRK takes part in the generation and development of the tumor.

Key words:Gene expression regulation, neoplastic,Cyclin-dependent kinases,Cell cycle