肺癌表皮生长因子受体酪氨酸激酶抑制剂获得性耐药的逆转

摘要/Abstract

摘要：以表皮生长因子受体（EGFR）为靶点治疗非小细胞肺癌是治疗肺癌的前沿手段，其产生的获得性耐药限制了靶向药物的发展。目前已有大量的有关EGFR突变耐药的数据，利用这些数据，人们正在探讨克服EGFR靶向治疗耐药的3个基本方法：强化EGFR的抑制、EGFR抑制剂与其他靶向治疗相结合以及通过替代途径改变抗癌治疗方法。

李辰晨, 冯继锋. 肺癌表皮生长因子受体酪氨酸激酶抑制剂获得性耐药的逆转[J]. 国际肿瘤学杂志, 2013, 40(11): 843-846.

LI Chen-Chen, FENG Ji-Feng. Reversal for acquired resistance to EGFR inhibitors in lung cancer[J]. Journal of International Oncology, 2013, 40(11): 843-846.

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肺癌表皮生长因子受体酪氨酸激酶抑制剂获得性耐药的逆转

Reversal for acquired resistance to EGFR inhibitors in lung cancer

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