国际肿瘤学杂志››2014,Vol. 41››Issue (1): 4-7.doi:10.3760/cma.j.issn.1673422X.2014.01.002

• 综述 •上一篇下一篇

血小板内皮细胞黏附分子-1与肿瘤

刘芳, 贾晓艳, 王若雨

  1. 116001大连大学附属中山医院肿瘤内科(刘芳、王若雨);大连大学附属新华医院病理科(贾晓艳)
  • 出版日期:2014-01-08发布日期:2014-01-22
  • 通讯作者:王若雨,E-mail:wry1963@sohu.com E-mail:wry1963@sohu.com
  • 基金资助:

    国家自然科学基金(30970869)

Plateletendothelial cell adhesion molecule1 and tumor

LIU Fang, JIA Xiao-Yan, WANG Ruo-Yu

  1. Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China
  • Online:2014-01-08Published:2014-01-22

摘要:血小板内皮细胞黏附分子1(PECAM1)是免疫球蛋白超家族中的一种黏附分子,高表达于内皮细胞。近年来研究发现,PECAM1与肿瘤的发生、血管生成、细胞凋亡以及耐药均相关,可能对肿瘤的诊断与治疗产生重要影响。

关键词:抗原,CD31,肿瘤,新生血管化,病理性,细胞凋亡,抗药性,肿瘤

Abstract:Plateletendothelial cell adhesion molecule1 (PECAM1) is a adhesion molecule of the immunoglobulin superfamily, which is highly expressed in endothelial cells. Recent studies show that PECAM1 is related with tumorigenesis, angiogenesis, apoptosis and drug resistance, which may exert a significant influence on the diagnosis and treatment of tumor.

Key words:Antigens, CD31,Neoplasms,Neovascularization, pathologic,Apoptosis,Drug resistance, neoplasm