国际肿瘤学杂志››2014,Vol. 41››Issue (6): 463-466.doi:10.3760/cma.j.issn.1673422X.2014.06.019

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微小RNA与弥漫大B细胞淋巴瘤

王馨瑗,杨锡贵,姜超

  1. 250117济南,济南大学 betway.com 医学与生命科学学院(王馨瑗);山东省肿瘤医院内科(王馨瑗、杨锡贵、姜超)
  • 出版日期:2014-06-08发布日期:2014-05-08
  • 通讯作者:杨锡贵,Email:zlysxgy@126.com E-mail:zlysxgy@126.com

MicroRNA and diffuse large Bcell lymphoma

Wang Xinyuan*, Yang Xigui, Jiang Chao

  1. *School of Medical and Life Sciences, Shandong Academy of Medical Sciences, Jinan University; Department of Medical Oncology, Shandong Cancer Hospital, Jinan 250117, China
  • Online:2014-06-08Published:2014-05-08
  • Contact:Yang Xigui E-mail:zlysxgy@126.com

摘要:DNA甲基转移酶1(DNMT1)作为DNA甲基转移酶(DNMT)家族的主要成员,对维持和调节肿瘤细胞全基因组和局部区域甲基化起着核心作用。DNMT1在妇科恶性肿瘤中高表达,引起基因DNA的甲基化异常,特别是抑癌基因的高甲基化,继而造成相关基因表达沉默,导致细胞的恶性生长。

关键词:微RNAs,淋巴瘤,大B细胞,弥漫性

Abstract:MicroRNA (miRNA) is a kind of naturally occurring short noncoding small molecular RNA, which regulates gene expression at the posttranscriptional level through its sequence complementation with target mRNAs. Researches have shown that different malignant tumors, including diffuse large B cell lymphoma, have specific miRNA expression profiles. Therefore, miRNAs expression level of specimens of body fluids and tissues is expected to be the new indicator for assessing diffuse large B cell lymphoma.

Key words:MicroRNAs,Lymphoma,large Bcell,diffuse