国际肿瘤学杂志››2014,Vol. 41››Issue (11): 811-812.doi:10.3760/cma.j.issn.1673-422X.2014.11.004

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周期素依赖性激酶10与肿瘤发生

  1. 漯河医学高等专科学校药学系
  • 出版日期:2014-12-03发布日期:2015-01-20
  • 通讯作者:游颜杰,Email: youyanjie@163.com
  • 基金资助:

    河南省科技攻关计划(142102310464)

Cyclin-dependent kinase 10 and tumorigenesis

  1. Department of Pharmacy, Luohe Medical College, Luohe 462002, China
  • Online:2014-12-03Published:2015-01-20
  • Contact:You Yanjie, Email: youyanjie@163.com

摘要:周期素依赖性激酶10(CDK10)通过与转录因子Ets2相互作用参与调控细胞周期,发挥抑癌基因的作用。研究表明CDK10表达下调与多种肿瘤形成密切相关,提示CDK10有希望成为针对恶性肿瘤的潜在分子诊断标志物和治疗靶点。

关键词:基因,肿瘤抑制,肿瘤,肿瘤标记,生物学,诊断

Abstract:Cyclindependent kinase 10 (CDK10) function as a tumor suppressor gene through regulating cell cycle interacting with transcription factor Ets2. Studies demonstrate that the downregulation of CDK10 expression occurs in multiple cancer types, indicating a potential application of CDK10 as a molecular diagnostic marker as well as therapeutic target.

Key words:Genes, tumor suppressor,Neoplasms,Tumor markers, biological,Diagnosis