长链非编码RNA MEG3在肿瘤中的研究

摘要/Abstract

摘要：母源性印记基因3（MEG3）是一种肿瘤抑制基因，其转录产物不编码蛋白，属长链非编码RNA。在人类多种肿瘤组织及细胞株中存在MEG3基因表达缺失，DNA甲基化程度升高等机制与之密切相关。研究表明，MEG3基因及其转录产物能够抑制肿瘤细胞增殖，并促进肿瘤细胞凋亡，其抑癌机制与肿瘤抑制基因p53的作用密不可分。

陈瑞东,唐文,胡端敏. 长链非编码RNA MEG3在肿瘤中的研究[J]. 国际肿瘤学杂志, 2015, 42(2): 118-121.

Chen Ruidong, Tang Wen, Hu Duanmin. Research progress of MEG3 long noncoding RNA[J]. Journal of International Oncology, 2015, 42(2): 118-121.

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长链非编码RNA MEG3在肿瘤中的研究

Research progress of MEG3 long noncoding RNA

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