X染色体耦联锌指蛋白在肿瘤发生发展中的研究进展

摘要/Abstract

摘要：X染色体耦联锌指蛋白（Zfx）是锌指蛋白家族的一员，在多种干细胞和恶性肿瘤细胞中异常表达，研究表明其在干细胞的自我更新以及肿瘤细胞增殖、凋亡和迁移等方面发挥重要的作用。

闫磊磊, 彭佳远, 汪昱. X染色体耦联锌指蛋白在肿瘤发生发展中的研究进展[J]. 国际肿瘤学杂志, 2014, 41(12): 890-893.

YAN Lei-Lei, PENG Jia-Yuan, WANG Yu. Role of zincfinger protein X-linked in the development of neoplasms[J]. Journal of International Oncology, 2014, 41(12): 890-893.

［1］ Miller J, McLachlan AD, Klug A. Repetitive zincbinding domains in the protein transcription factor IIIA from Xenopus oocytes［J］. EMBO J, 1985, 4(6): 16091614. ［2］ Hoovers JM, Mannens M, John R, et al. Highresolution localization of 69 potential human zinc finger protein genes: a number are clustered［J］. Genomics, 1992, 12(2): 254263. ［3］ Chandrasekharan S, Kumar S, Valley CM, et al. Proprietary science, open science and the role of patent disclosure: the case of zincfinger proteins［J］. Nat biotechnol, 2009, 27(2): 140144. ［4］ Schnidar H, Eberl M, Klingler S, et al. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway［J］. Cancer Res, 2009, 69(4): 12841292. ［5］ Poloumienko A. Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY［J］. Genome, 2004, 47(1): 7483. ［6］ SchneiderGdicke A, BeerRomero P, Brown LG, et al. Putative transcription activator with alternative isoforms encoded by human ZFX gene［J］. Nature, 1989, 342(6250): 708711. ［7］ Fortunel NO, Otu HH, Ng HH, et al. Comment on " ′Stemness′: transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature"［J］. Science, 2003, 302(5644): 393393. ［8］ Huang D, Gao Q, Guo L, et al. Isolation and identification of cancer stemlike cells in esophageal carcinoma cell lines［J］. Stem Cells Dev, 2009, 18(3): 465474. ［9］ RamalhoSantos M, Yoon S, Matsuzaki Y, et al. "Stemness": transcriptional profiling of embryonic and adult stem cells［J］. Science, 2002, 298(5593): 597600. ［10］ GalanCaridad JM, Harel S, Arenzana TL, et al. Zfx controls the selfrenewal of embryonic and hematopoietic stem cells［J］. Cell, 2007, 129(2): 345357. ［11］ Ivanova N, Dobrin R, Lu R, et al. Dissecting selfrenewal in stem cells with RNA interference［J］. Nature, 2006, 442(7102): 533538. ［12］ Zhou Y, Su Z, Huang Y,et al. The Zfx gene is expressed in human gliomas and is important in the proliferation and apoptosis of the human malignant glioma cell line U251［J］. J Exp Clin Cancer Res, 2011, 30: 114. ［13］ Zhu Z, Li K, Xu D, et al. ZFX regulates glioma cell proliferation and survival in vitro and in vivo［J］. J Neurooncol, 2013, 112(1): 1725. ［14］ Wang J, Wang H, Li Z, et al. cMyc is required for maintenance of glioma cancer stem cells［J］. PLoS One, 2008, 3(11): e3769. ［15］ Hendruschk S, Wiedemuth R, Aigner A, et al. RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo［J］. Neuro Oncol, 2011, 13(10): 10741089. ［16］ Komata T, Kanzawa T, Takeuchi H, et al. Antitumour effect of cyclindependent kinase inhibitors (p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1) on malignant glioma cells［J］. Br J Cancer, 2003, 88(8): 12771280. ［17］ Fang X, Huang Z, Zhou W, et al. The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells［J］. Stem Cells, 2014, 32(8): 20332047. ［18］ Zheng H, Ying H, Yan H, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation［J］. Nature, 2008, 455(7216): 11291133. ［19］ Radke J, Bortolussi G, Pagenstecher A. Akt and cMyc induce stemcell markers in mature primary p53-/- astrocytes and render these cells gliomagenic in the brain of immunocompetent mice［J］. PloS one, 2013, 8(2): e56691. ［20］ Li K, Zhu ZC, Liu YJ, et al. ZFX knockdown inhibits growth and migration of nonsmall cell lung carcinoma cell line H1299［J］. Int J Exp Pathol, 2013, 6(11): 24602467. ［21］ Namls HM, MezaZepeda LA, Bary T, et al. Modulation of the osteosarcoma expression phenotype by microRNAs［J］. PLoS One, 2012, 7(10): e48086. ［22］ Guled M, Lahti L, Lindholm PM, et al. CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma  A miRNA microarray analysis［J］. Genes Chromosomes Cancer, 2009, 48(7): 615623. ［23］ Zha W, Cao L, Shen Y, et al. Roles of Mir144ZFX Pathway in Growth Regulation of NonSmallCell Lung Cancer［J］. PLoS One, 2013, 8(9): e74175. ［24］ Akiyoshi S, Fukagawa T, Ueo H, et al. Clinical significance of miR144ZFX axis in disseminated tumour cells in bone marrow in gastric cancer cases［J］. Br J Cancer, 2012, 107(8): 13451353. ［25］ Wu S, Lao XY, Sun TT, et al. Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo downregulating the ERKMAPK pathway［J］. Cancer Lett, 2013, 337(2): 293300. ［26］ Lai KP, Chen J, He M, et al. Overexpression of ZFX confers selfrenewal and chemoresistance properties in hepatocellular carcinoma［J］. Int J Cancer, 2014, 135(8): 17901799.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲.血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华.Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青.血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺.PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云.新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚.EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六.基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六.肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳.炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝.癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志.宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.

X染色体耦联锌指蛋白在肿瘤发生发展中的研究进展

Role of zincfinger protein X-linked in the development of neoplasms

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章15

编辑推荐

Metrics

本文评价