瞬时受体电位C在肿瘤中的作用

国际肿瘤学杂志››2015,Vol. 42››Issue (7): 522-524.doi:10.3760/cma.j.issn.1673-422X.2015.07.012

汪林军，华东

214062 苏州大学附属第四医院(无锡市第四人民医院)肿瘤内科

出版日期:2015-07-08发布日期:2015-05-26
通讯作者:华东 E-mail:wx89211@163.com
基金资助:

江苏省临床医学科技专项（BL2014019）

Roles of transient receptor potential canonical channels in tumors

Wang Linjun, Hua Dong

Department of Oncology, Fourth Affiliated Hospital of Soochow University & Wuxi Fourth People′s Hospital, Wuxi 214062, China

Online:2015-07-08Published:2015-05-26
Contact:Hua Dong E-mail:wx89211@163.com

摘要/Abstract

摘要：瞬时受体电位（TRP）通道作为一种重要的非选择性阳离子通道家族，主要通透Ca2+、Na+等阳离子。TRPC通道是TRP家族的一个亚族，调控第二信使Ca2+的浓度及各种蛋白酶的活性，从而直接或间接影响细胞的生物学行为。近年研究证明，TRPC通道调控肿瘤细胞增殖、分化、转移、细胞凋亡以及对化学药物的敏感性，影响肿瘤发生和发展。

关键词:肿瘤,经典瞬时受体电位通道

Abstract:Transient receptor potential (TRP) channels as an important nonselective cation channels family mainly permeate Ca2+, Na+ and other cations. TRPC channel is a subtribe of TRP family which regulates the second messenger of Ca2+ concentration and variety of protease activity, and which can directly or indirectly affect the biological behavior of cells. Recently, more and more evidences have certificated the TRPC channels affect the tumorigenesis and development, such as regulation of proliferation, differentiation, migration, apoptosis and resistance of chemotherapeutic agents during cancer progression.

Key words:Neoplasms,Transient receptor potential canonical channel

汪林军，华东. 瞬时受体电位C在肿瘤中的作用[J]. 国际肿瘤学杂志, 2015, 42(7): 522-524.

Wang Linjun, Hua Dong. Roles of transient receptor potential canonical channels in tumors[J]. Journal of International Oncology, 2015, 42(7): 522-524.

参考文献

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