长非编码RNA UCA1在肿瘤中的研究进展

国际肿瘤学杂志››2016,Vol. 43››Issue (1): 29-31.doi:10.3760/cma.j.issn.1673-422X.2016.01.008

长非编码RNA UCA1在肿瘤中的研究进展

史有阳,钱亚云

225009 扬州大学医学院中西医结合学系

收稿日期:2015-05-07出版日期:2016-01-08发布日期:2015-12-03
通讯作者:钱亚云 E-mail:yyqian@yzu.edu.cn
基金资助:

国家自然科学基金（81403232、81450051）

Research progress of long non-coding RNA UCA1 in tumor

Shi Youyang, Qian Yayun

Department of Integrative Medicine, Medical School, Yangzhou University, Yangzhou 225009, China

Received:2015-05-07Online:2016-01-08Published:2015-12-03
Contact:Qian Yayun E-mail:yyqian@yzu.edu.cn
Supported by:

National Natural Science Foundation of China (81403232, 81450051)

摘要/Abstract

摘要：作为一种原癌基因，尿路上皮癌抗原1（UCA1）在膀胱癌、胃癌、乳腺癌、卵巢癌、脑胶质瘤等多种肿瘤中均呈高表达，在肿瘤的诊断、治疗和预后中均显示出重要的应用价值。研究表明UCA1可通过多条信号通路和多种分子机制促进肿瘤细胞增殖，可能成为肿瘤诊断及治疗的潜在新靶点。

史有阳,钱亚云. 长非编码RNA UCA1在肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2016, 43(1): 29-31.

Shi Youyang, Qian Yayun. Research progress of long non-coding RNA UCA1 in tumor[J]. Journal of International Oncology, 2016, 43(1): 29-31.

［1］ Wang XS, Zhang Z, Wang HC, et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladdercarcinoma［J］. Clin Cancer Res, 2006, 12 (16): 4851-4858. DOI:10.1158/10780432.CCR-06-0134. ［2］ Xue M, Li X, Wu W, et al. Upregulation of long noncoding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis［J］. Oncol Rep, 2014, 31(5): 1993-2000. DOI:10.3892/or.2014.3092. ［3］ Xie XJ, Li X, Wang F, et al. Cellular localization and tissue expression pattern of UCA1, a noncoding RNA［J］. Nan Fang Yi Ke DaXue Xue Bao, 2010, 30(1): 57-60. ［4］ Rafiee P, Shi Y, Su J, et al. Erythropoietin protects the infant heart against ischemiareperfusion injury by triggering multiple signaling pathways［J］. Basic Res Cardiol, 2005, 100(3): 187-197. ［5］ Codolo G, Munari F, Fassan M, et al. Evaluation of the efficacy of the H. pylori protein HPNAP as a therapeutic tool for treatment of bladder cancer in an orthotopic murine model［J］. J Vis Exp, 2015, 99: e52743. DOI:10.3791/52743. ［6］ Zhang Z, Hao H, Zhang CJ, et al. Evaluation of novel gene UCA1 as a tumor biomarker for the detection of bladder［J］. Zhonghua Yi Xue Za Zhi, 2012, 92(6): 384-387. ［7］ Wang F, Li X, Xie X, et al. UCA1, a nonproteincoding RNA upregulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion［J］. FEBS Letters, 2008, 582(13): 1919-1927. DOI:10.1016/j.febslet.2008.05.012. ［8］ Fan Y, Shen B, Tan M, et al. Long noncoding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling［J］. FEBS J, 2014, 281(7): 1750-1758. DOI:10.1111/febs.12737. ［9］ Yang C, Li X, Wang Y, et al. Long noncoding RNA UCA1 regulated cell cycle distribution via CREB through PI3K dependent pathway in bladder carcinoma cells［J］. Gene, 2012, 496(1): 8-16. DOI:10.1016/j.gene.2012.01.012. ［10］ Wang X, Gong X, Jin B, et al. Long noncoding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells［J］. Oncology Rep, 2014, 32(3): 1281-1290. DOI:10.3892/or.2014.3309. ［11］ Gu W, Gao T, Sun Y, et al. LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis［J］. Cancer Biomark, 2015, 15(3): 249-258. DOI:10.3233/CBM-150460. ［12］ Han Y, Yang YN, Yuan HH, et al. UCA1, a long noncoding RNA upregulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution［J］. Pathology, 2014, 46(5): 396-401. DOI:10.1097/PAT.0000000000000125. ［13］ Li JY, Ma X, Zhang CB. Overexpression of long noncoding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma［J］. Int J Clin Exp Pathol, 2014, 7(11): 7938-7944. ［14］ Huang J, Zhou N, Watabe K, et al. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)［J］. Cell Death Dis, 2014, 5：e1008. DOI:10.1038/cddis.2013.541. ［15］杨慧, 余敏敏, 陆晓媛. 长链非编码RNA在宫颈癌及宫颈上皮内瘤样病变中的表达［J］. 江苏医药, 2014, 40(22): 2685-2688. ［16］ Lim D, Olive E. Precursors and pathogenesis of ovarian carcinoma［J］. Pathology, 2013, 45(3): 229-242. DOI:10.1097/PAT.0b013e32835f2264. ［17］ Wang F, Zhou J, Xie X, et al. Involvement of SRPK1 in cisplatin resistance related to long noncoding RNA UCA1 in human ovarian cancer cells［J］. Neoplasma, 2015, 62(3): 432-438. DOI:10.4149/neo/2015/051. ［18］ Gerstner ER, Batchelor TT. Imaging and response criteria in gliomas［J］. Curr Opin Oncol, 2010, 22(6): 598-603. DOI:10.1097/CCO.0b013e32833de96e. ［19］孙阳. 长链非编码RNA在脑胶质瘤中差异表达的相关研究［D］. 长春: 吉林大学, 2014. ［20］ Tsang WP, Wong TW, Cheung AH, et al. Induction of drug resistance and transformation in human cancer cells by the noncodingRNA CUDR［J］. RNA, 2007, 13(6): 890-898. DOI:10.1261/rna.359007. ［21］ Tian Y, Zhang X, Hao Y, et al. Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma[J]. Melanoma Res, 2014, 24(4): 335-341. DOI:10.1097/CMR.0000000000000080. ［22］ Fang Z, Wu L, Wang L, et al. Increased expression of the long noncoding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis［J］. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(1): 8995. DOI:10.1016/j.oooo.2013.09.007.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲.血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华.Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青.血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺.PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云.新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚.EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六.基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六.肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳.炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝.癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志.宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.