二甲双胍抗肿瘤及调控HIF-1α的作用

摘要/Abstract

摘要：研究发现二甲双胍对多种恶性肿瘤的增殖均有显著抑制作用，提示二甲双胍的抗肿瘤作用。二甲双胍可减少肿瘤细胞氧的消耗，经转录及转录后机制抑制缺氧诱导因子1α（HIF-1α）的聚集，通过激活腺苷酸活化蛋白激酶（AMPK）抑制HIF-1α的表达。

高君蓉, 张倜, 曹曼卿, 张雪君, 朱晓琳. 二甲双胍抗肿瘤及调控HIF-1α的作用[J]. 国际肿瘤学杂志, 2016, 43(2): 113-.

GAO Jun-Rong, ZHANG Ti, CAO Man-Qing, ZHANG Xue-Jun, ZHU Xiao-Lin. Anticancer effect of metformin and regulation on HIF-1α[J]. Journal of International Oncology, 2016, 43(2): 113-.

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二甲双胍抗肿瘤及调控HIF-1α的作用

Anticancer effect of metformin and regulation on HIF-1α

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