HOXC基因在肿瘤中的表达与作用

国际肿瘤学杂志››2016,Vol. 43››Issue (6): 436-438.doi:10.3760/cma.j.issn.1673-422X.2016.06.009

李琳，贾秀红

256603 滨州医学院附属医院儿科

收稿日期:2015-07-25出版日期:2016-06-08发布日期:2016-04-27
通讯作者:贾秀红 E-mail:jiaxiuhong001@163.com
基金资助:

山东省自然科学基金（ZR2014HL032）；山东省医药卫生科技发展计划（2014WS0183）

Expression and role of HOXC gene in tumor

Li Lin, Jia Xiuhong

Department of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, China

Received:2015-07-25Online:2016-06-08Published:2016-04-27
Contact:Jia Xiuhong E-mail:jiaxiuhong001@163.com
Supported by:

Natural Science Foundation of Shandong Province of China (ZR2014HL032); Medical Science and Technique Program of Shandong Province of China (2014WS0183)

摘要/Abstract

摘要：HOXC基因簇作为同源盒（HOX）基因家族的一员，在多种器官中均有表达，具有调控基因表达、细胞分化和机体形态发生的功能，而其功能的异常与白血病、乳腺癌、肾细胞癌、前列腺癌等肿瘤的预后密切相关。

李琳，贾秀红. HOXC基因在肿瘤中的表达与作用[J]. 国际肿瘤学杂志, 2016, 43(6): 436-438.

Li Lin, Jia Xiuhong. Expression and role of HOXC gene in tumor[J]. Journal of International Oncology, 2016, 43(6): 436-438.

［1］ Durston AJ, Jansen HJ, In der Rieden P, et al. Hox collinearitya new perspective［J］. Int J Dev Biol, 2011, 55(10-12): 899-908. DOI: 10.1387/ijdb.113358ad. ［2］ Tosi′c N, Stojiljkovi′c M, Colovi′c N, et al. Acute myeloid leukemia with NUP98HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review［J］. Cancer Genet Cytogenet, 2009, 193(2): 98-103. DOI: 10.1016/j.cancergencyto.2009.03.007. ［3］ Wan Y, Chang HY. HOTAIR: Flight of noncoding RNAs in cancer metastasis［J］. Cell Cycle, 2010, 9(17): 3391-3392. ［4］ Shah N, Sukumar S. The Hox genes and their roles in oncogenesis［J］. Nat Rev Cancer, 2010, 10(5): 361-371. DOI: 10.1038/nrc2826. ［5］ He S, Liu S, Zhu H. The sequence, structure and evolutionary features of HOTAIR in mammals［J］. BMC Evol Biol, 2011, 11: 102. ［6］ Xing CY, Hu XQ, Xie FY, et al. Long noncoding RNA HOTAIR modulates cKIT expression through sponging miR193a in acute myeloid leukemia［J］. FEBS Lett, 2015, 589(15): 1981-1987. DOI: 10.1016/j.febslet.2015.04.061. ［7］ Ansari KI, Hussain I, Shrestha B, et al. HOXC6 is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment［J］. J Mol Biol, 2011, 411(2): 334349. DOI: 10.1016/j.jmb.2011.05.050. ［8］ Hur H, Lee JY, Yun HJ, et al. Analysis of HOX gene expression patterns in human breast cancer［J］. Mol Biotechnol, 2014, 56(1): 64-71. DOI: 10.1007/s1203301396824. ［9］ Wu Y, Liu J, Zheng Y, et al. Suppressed expression of long noncoding RNA HOTAIR inhibits proliferation and tumourigenicity of renal carcinoma cells［J］. Tumour Biol, 2014, 35(12): 11887-11894. DOI: 10.1007/s13277-014-2453-4. ［10］ Pei CS, Wu HY, Fan FT, et al. Influence of curcumin on HOTAIRmediated migration of human renal cell carcinoma cells［J］. Asian Pac J Cancer Prev, 2014, 15(10): 4239-4243. ［11］ Cantile M, Franco R, Schiavo G, et al. The HOX genes network in urogenital cancers: mechanisms and potential therapeutic implications［J］. Curr Med Chem, 2011, 18(32): 4872-4884. ［12］ Liu YJ, Zhu Y, Yuan HX, et al. Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis［J］. Tumour Biol, 2015, 36(4): 2821-2829. DOI: 10.1007/s13277-014-2909-6. ［13］ Chiyomaru T, Yamamura S, Fukuhara S, et al. Genistein inhibits prostate cancer cell growth by targeting miR34a and oncogenic HOTAIR［J］. PLoS One, 2013, 8(8): e70372. DOI: 10.1371/journal.pone.0070372. ［14］ Axlund SD, Lambert JR, Nordeen SK. HOXC8 inhibits androgen receptor signaling SRC-3 recruitment to direct androgen target genes［J］. Mol Cancer Res, 2010, 8(12): 1643-1655. ［15］王刘江. 前列腺癌危险度分级与术后Gleason评分、PSA的关系的研究［D］. 杭州: 浙江大学, 2013. ［16］ Waltregny D, Alami Y, Clausse N, et al. Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation［J］. Prostate, 2002, 50(3): 162-169. ［17］ Kocak H, Ackermann S, Hero B, et al. HoxC9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma［J］. Cell Death Dis, 2013, 4: e586. DOI: 10.1038/cddis.2013.84. ［18］ Mao L, Ding J, Zha Y, et al. HOXC9 links cellcycle exit and neuronal differentiation and is a prgnostic marker in neuroblastoma［J］. Cancer Res, 2011, 71(12): 4314-4324. DOI: 10.1158/0008-5472.CAN-11-0051. ［19］朱永洁, 陈鑫, 邴春梅, 等. 神经母细胞瘤组织中HOXC9蛋白的表达与肿瘤发展及预后的关系［J］. 山东医药, 2014, 54(43): 25-27. DOI: 10.3969/j.issn.1002266X.2014.43.008. ［20］ Cantile M, Galletta F, Franco R, et al. Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in welldifferentiated and dedifferentiated human liposarcomas［J］. Oncol Rep, 2013, 30(6): 2579-2586. DOI: 10.3892/or.2013.2760. ［21］ Du YB, Dong B, Shen LY, et al. The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma［J］. J Surg Res, 2014, 188(2): 442-450. DOI: 10.1016/j.jss.2014.01.017. ［22］ Moon SM, Kim SA, Yoon JH, et al. HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression［J］. J Biol Chem, 2012, 287(42): 35678-35688. DOI: 10.1074/jbc.M112.361675. ［23］ Zhai Y, Kuick R, Nan B, et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion［J］. Cancer Res, 2007, 67(21): 10163-10172. DOI: 10.1158/00085472.CAN-07-2056. ［24］ Zhang Q, Jin XS, Yang ZY, et al. Upgredulated Hoxc6 expression is associated with poor survival in gastric cancer patients［J］. Neoplasma, 2013, 60(4): 439-445. DOI: 10.4149/neo_2013_057.

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